The bioinformatics toolbox for circRNA discovery and analysis

• Published in: Briefings in bioinformatics Vol. 22; no. 2; pp. 1706 - 1728
• Main Authors: Chen, Liang, Wang, Changliang, Sun, Huiyan, Wang, Juexin, Liang, Yanchun, Wang, Yan, Wong, Garry
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 22.03.2021; Oxford Publishing Limited (England)
• Subjects: Annotations; Bioinformatics; Biomarkers; Data mining; Gene sequencing; Network analysis; Review; Ribonucleic acid; RNA; Splicing; text mining; circRNA; non-coding RNA; next generation sequencing; bioinformatics tools; disease biomarker

Abstract Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent advances in sequencing technologies and bioinformatics tools have led directly to an ever-expanding field of types a...