Characterisation of a novel transcript LNPPS acting as tumour suppressor in bladder cancer via PDCD5‐mediated p53 degradation blockage

• Published in: Clinical and translational medicine Vol. 13; no. 1; pp. e1149 - n/a
• Main Authors: Li, Juan, Wang, Yifan, Zhang, Xinya, Yang, Xuemei, Qi, Qiuchen, Mi, Qi, Feng, Maoxiao, Wang, Yunshan, Wang, Chuanxin, Li, Peilong, Du, Lutao
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2023; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Antibodies; Apoptosis; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Bladder cancer; Cancer therapies; Cell Line, Tumor; Chemotherapy; Clinical medicine; DNA Damage; Fractions; Humans; lncRNA; m6A; Mice; Neoplasm Proteins - genetics; Plasmids; Polymerase chain reaction; Proteins; Reagents; RNA, Long Noncoding; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumors; ubiquitination; Urinary Bladder Neoplasms - genetics; Beijing China; United States > US; China; Germany; m6A; lncRNA; ubiquitination; bladder cancer

Background Long non‐coding RNAs (lncRNAs) play a crucial role in tumour initiation and progression. However, little is known about their contributions to p53‐related bladder cancer (BC) inhibition. Methods By using high‐throughput sequencing, we screened the expression profiles of lncRNAs in BC and...