An Enzymatic Route to Selenazolines
Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates...
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Published in | Chembiochem : a European journal of chemical biology Vol. 14; no. 5; pp. 564 - 567 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Weinheim
WILEY-VCH Verlag
18.03.2013
WILEY‐VCH Verlag Wiley Subscription Services, Inc |
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Abstract | Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines. |
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AbstractList | Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines. |
Author | Morawitz, Falk Fuszard, Matthew A. Smellie, Iain A. Botting, Catherine H. Smith, Margaret C. M. Bent, Andrew F. Shirran, Sally L. Houssen, Wael E. Jaspars, Marcel Naismith, James H. Koehnke, Jesko |
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Snippet | Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic... |
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SubjectTerms | Amino Acid Sequence biochemistry biosynthesis Communications Cysteine - chemistry Cysteine - metabolism Iodoacetamide - chemistry Multienzyme Complexes - metabolism Oxazoles - chemistry Oxazoles - metabolism patellamides Peptides, Cyclic - biosynthesis Peptides, Cyclic - chemistry selenazolines Selenium - chemistry Selenium - metabolism Selenocysteine - chemistry Selenocysteine - metabolism Serine - chemistry Serine - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Thiazoles - chemistry Thiazoles - metabolism Threonine - chemistry Threonine - metabolism |
Title | An Enzymatic Route to Selenazolines |
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