Cytokine Dysregulation in Aged Horses and Horses with Pituitary Pars Intermedia Dysfunction

• Published in: Journal of veterinary internal medicine Vol. 22; no. 2; pp. 436 - 442
• Main Authors: McFarlane, D, Holbrook, T.C
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.03.2008
• Subjects: age; Aging - physiology; Animals; Cushing syndrome; cytokines; Cytokines - genetics; Cytokines - metabolism; endocrine diseases; Equine Cushing's disease; Gene Expression Regulation; Geriatric; Horse Diseases - metabolism; Horses; Inflammation; Pituitary Diseases - metabolism; Pituitary Diseases - physiopathology; Pituitary Diseases - veterinary; Pituitary Gland - physiopathology; Pituitary Gland, Intermediate - metabolism; Pituitary Gland, Intermediate - physiopathology; RNA, Messenger - metabolism; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - metabolism

Background: Equine pituitary pars intermedia dysfunction (PPID) is the result of a loss of dopaminergic inhibition of the pars intermedia secondary to neurodegeneration of periventricular hypothalamic neurons. The pathologic events contributing to development of neurodegeneration or clinical signs i...