Age‐related changes of skeletal muscle metabolic response to contraction are also sex‐dependent

• Published in: The Journal of physiology Vol. 603; no. 1; pp. 69 - 86
• Main Authors: Campbell, Matthew D., Djukovic, Danijel, Raftery, Daniel, Marcinek, David J.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2025; John Wiley and Sons Inc
• Subjects: Age; Aging - physiology; Animals; Bioenergetics; Carnitine; Electrical stimuli; Energy Metabolism - drug effects; Female; Females; Glutamic Acid - metabolism; high‐intensity intervals; low‐intensity steady‐state; Male; Metabolic pathways; Metabolic response; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria, Muscle - drug effects; Mitochondria, Muscle - metabolism; mitochondrial adaptation; Muscle; Muscle contraction; Muscle Contraction - physiology; Muscle, Skeletal - drug effects; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Musculoskeletal system; Oligopeptides - pharmacology; Oxidation; Peptides; Recovery of function; Respiration; sarcopenia; Sex; Sex Characteristics; sex specific effects; Skeletal muscle; mitochondrial adaptation; low‐intensity steady‐state; high‐intensity intervals; metabolism; sex specific effects; age; sarcopenia

Mitochondria adapt to increased energy demands during muscle contraction by acutely altering metabolite fluxes and substrate oxidation. With age, an impaired mitochondrial metabolic response may contribute to reduced exercise tolerance and decreased skeletal muscle mass, specific force, increased ov...