At equipotent doses, isradipine is better tolerated than amlodipine in patients with mild‐to‐moderate hypertension: a double‐blind, randomized, parallel‐group study

• Published in: British journal of clinical pharmacology Vol. 38; no. 4; pp. 335 - 340
• Main Authors: Hermans, L, Deblander, A, Keyser, P, Scheys, I, Lesaffre, E, Westelinck, KJ
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.1994; Blackwell Science
• Subjects: Adult; Aged; Amlodipine - administration & dosage; Amlodipine - adverse effects; Amlodipine - pharmacology; Amlodipine - therapeutic use; Ankle; Belgium; Biological and medical sciences; Blood Pressure - drug effects; Delayed-Action Preparations; Double-Blind Method; Drug toxicity and drugs side effects treatment; Edema - chemically induced; Female; Humans; Hypertension - drug therapy; Isradipine - administration & dosage; Isradipine - adverse effects; Isradipine - pharmacology; Isradipine - therapeutic use; Male; Medical sciences; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); Nausea - chemically induced; Patient Compliance; Pharmacology. Drug treatments; Surveys and Questionnaires; Therapeutic Equivalency; Belgium; Human; Hypertension; Chemotherapy; Randomization; Questionnaire; Treatment; Toxicity; Calcium antagonist; Double blind study; Cardiovascular disease; Dihydropyridine derivative

1. The objective of this double‐blind parallel‐group study was to compare the tolerability of isradipine and amlodipine, specifically, the side‐effects known to be related to the use of dihydropyridine calcium antagonists. 2. A total of 205 patients with mild‐to‐moderate essential hypertension were...