Apoptosis of Mycobacterium avium‐infected macrophages is mediated by both tumour necrosis factor (TNF) and Fas, and involves the activation of caspases

• Published in: Clinical and experimental immunology Vol. 116; no. 1; pp. 94 - 99
• Main Authors: BERMUDEZ, L. E., PARKER, A., PETROFSKY, M.
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.04.1999; Blackwell; Oxford University Press; Blackwell Science Inc
• Subjects: apoptosis; Apoptosis - drug effects; Bacterial diseases; Biological and medical sciences; Caspase 1 - metabolism; Caspase Inhibitors; caspases; Caspases - metabolism; Enzyme Activation; fas Receptor - metabolism; Human bacterial diseases; Humans; Infectious diseases; macrophages; Macrophages - immunology; Macrophages - microbiology; Medical sciences; Mycabacterium avium; Mycobacterium avium; Mycobacterium avium - immunology; Mycobacterium smegmatis - immunology; Original; Signal Transduction; Tuberculosis and atypical mycobacterial infections; Tumor Necrosis Factor-alpha - metabolism; Human; Fas antigen; Pathophysiology; Cytokine; Mycobacterium avium; Caspase; In vitro; Defense; Infection; Membrane receptor; Mycobacteriales; Mycobacteriaceae; Bacteriosis; Bacteria; Tumor necrosis factor β; Actinomycetes; Tumor necrosis factor α; Apoptosis; Macrophage; Biological receptor

Mycobacterium avium causes disseminated infection in AIDS patients and several forms of infection in immunocompetent hosts. Recent studies have shown that M. avium infection of macrophages in vitro leads to apoptosis of significant numbers of infected cells. Several strains of M. avium used to infec...