Translational applications of microRNAs in cancer, and therapeutic implications

The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therap...

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Published inNon-coding RNA research Vol. 2; no. 3-4; pp. 143 - 150
Main Authors Kwok, Grace T., Zhao, Jing Ting, Weiss, Jocelyn, Mugridge, Nancy, Brahmbhatt, Himanshu, MacDiarmid, Jennifer A., Robinson, Bruce G., Sidhu, Stan B.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2017
KeAi Publishing
KeAi Communications Co., Ltd
Subjects
Cancer
MicroRNAs
Rare cancers
Translational medicine
Rare cancers
MicroRNAs
Translational medicine
Cancer
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Summary:The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therapy or a tool to sensitise patients to treatment modalities such as chemotherapy and radiotherapy. We take a particular perspective towards miRNAs and their impact on rare cancers. Advancement in the delivery of miRNAs, from viral vectors and liposomal delivery to nanoparticle based, has led to a number of pre-clinical and clinical applications for microRNA cancer therapeutics. This is promising, especially in the setting of rare cancers.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:2468-0540
2468-0540
DOI:10.1016/j.ncrna.2017.12.002