Classical Complement Pathway Inhibition in a “Human‐On‐A‐Chip” Model of Autoimmune Demyelinating Neuropathies

• Published in: Advanced therapeutics Vol. 5; no. 6
• Main Authors: Rumsey, John W., Lorance, Case, Jackson, Max, Sasserath, Trevor, McAleer, Christopher W., Long, Christopher J., Goswami, Arindom, Russo, Melissa A., Raja, Shruti M., Gable, Karissa L., Emmett, Doug, Hobson‐Webb, Lisa D., Chopra, Manisha, Howard, James F., Guptill, Jeffrey T., Storek, Michael J., Alonso‐Alonso, Miguel, Atassi, Nazem, Panicker, Sandip, Parry, Graham, Hammond, Timothy, Hickman, James J.
• Format: Journal Article
• Language: English
• Published: Germany 01.06.2022
• Subjects: autoimmune demyelinating neuropathies; complement inhibition; drug efficacy; human‐on‐a‐chip; rare diseases; drug efficacy; human-on-a-chip; autoimmune demyelinating neuropathies; complement inhibition; Rare disease

Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here the authors describe a phenotypic, human‐on‐a‐chip (HoaC) electrical conduction model of two rare autoimmune demyelinating neuropathies, chronic inflammatory de...