Sparteine oxidation is practically abolished in quinidine‐treated patients
In eight patients a sparteine‐test was carried out immediately before and after 1 week of treatment with quinidine 600‐800 mg day‐1. Before treatment one patient was classified as a poor metaboliser (metabolic ratio: greater than or equal to 20), and seven patients as extensive metabolisers. During...
Saved in:
| Published in | British journal of clinical pharmacology Vol. 22; no. 2; pp. 194 - 197 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.08.1986
Blackwell Science |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | In eight patients a sparteine‐test was carried out immediately before and after 1 week of treatment with quinidine 600‐800 mg day‐1. Before treatment one patient was classified as a poor metaboliser (metabolic ratio: greater than or equal to 20), and seven patients as extensive metabolisers. During quinidine treatment, the formation of sparteine metabolites (2‐ and 5‐dehydrosparteine) was practically abolished. Patients initially classified as extensive metabolisers thus exhibited the phenotype of poor metabolisers during quinidine treatment. |
|---|---|
| AbstractList | In eight patients a sparteine-test was carried out immediately before and after 1 week of treatment with quinidine 600-800 mg day-1. Before treatment one patient was classified as a poor metaboliser (metabolic ratio: greater than or equal to 20), and seven patients as extensive metabolisers. During quinidine treatment, the formation of sparteine metabolites (2- and 5-dehydrosparteine) was practically abolished. Patients initially classified as extensive metabolisers thus exhibited the phenotype of poor metabolisers during quinidine treatment. |
| Author | Otton, SV Haghfelt, T. Gram, LF Brinn, R. Brosen, K. |
| Author_xml | – sequence: 1 givenname: R. surname: Brinn fullname: Brinn, R. – sequence: 2 givenname: K. surname: Brosen fullname: Brosen, K. – sequence: 3 givenname: LF surname: Gram fullname: Gram, LF – sequence: 4 givenname: T. surname: Haghfelt fullname: Haghfelt, T. – sequence: 5 givenname: SV surname: Otton fullname: Otton, SV |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7857902$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/3756067$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVkN1KwzAUx4Moc5s-glDE29akadLWC0WHXzBQUK_DaZu6jC6tSafbnY_gM_okpmwUvTQ3Cef_ccJvhHZ1rSVCxwQHxJ3TeUAoZ35IQhaQNOFBm2EWMhysdtCwl3bREFPMfaeQfTSydo4xoYSzARrQmHHM4yGaPjVgWqm09OqVKqBVtfaU9RoDeatyqKq1B1ldKTuThae097ZUWhXO__351RoJrRs3LiZ1aw_QXgmVlYfbe4xebq6fJ3f-9OH2fnI59XOGOfa5JGlEgHBaxpzGXIZhVHLIOM4B0zRJeQaQlUkkoQwZz2WUQpFmNMYsk1Ec0TE63_Q2y2whi9ztNlCJxqgFmLWoQYm_ilYz8Vq_CxJhx4-7grNNQW5qa40s-yzBokMs5qLjKDqOokMstojFyoWPfm_vo1umTj_Z6mAdwNKAzpXtbXHC4hSHznaxsX2oSq7_8QFxNXnsXvQH0umd2w |
| CODEN | BCPHBM |
| CitedBy_id | crossref_primary_10_1111_j_1365_2125_1992_tb04035_x crossref_primary_10_1034_j_1601_0825_2003_02892_x crossref_primary_10_1007_BF02220625 crossref_primary_10_1046_j_1365_2125_1998_00727_x crossref_primary_10_1111_j_1365_2125_1986_tb02911_x crossref_primary_10_1007_BF03259223 crossref_primary_10_1111_j_1365_2125_1990_tb03628_x crossref_primary_10_1177_154411130401500104 crossref_primary_10_1016_0006_2952_91_90189_C crossref_primary_10_1046_j_1365_2125_2003_01853_x crossref_primary_10_1046_j_1365_2125_2003_01851_x crossref_primary_10_1111_j_1365_2125_1989_tb05409_x crossref_primary_10_1111_j_1365_2125_1989_tb03557_x crossref_primary_10_1111_j_1365_2125_1991_tb05550_x crossref_primary_10_1016_0165_6147_90_90245_4 crossref_primary_10_2217_pgs_15_172 crossref_primary_10_1111_j_1365_2125_1989_tb05391_x crossref_primary_10_1007_s40261_014_0210_5 crossref_primary_10_3109_00498258909034691 crossref_primary_10_1111_j_1600_0714_2010_00897_x crossref_primary_10_1124_dmd_108_021394 crossref_primary_10_1016_0024_3205_91_90618_L crossref_primary_10_1046_j_1365_2125_1999_00029_x crossref_primary_10_1016_j_jns_2006_06_030 crossref_primary_10_1111_j_1365_2125_1990_tb03639_x crossref_primary_10_1046_j_1365_2125_2000_00120_x crossref_primary_10_1016_0163_7258_90_90096_K crossref_primary_10_1016_S0009_9236_96_90056_9 crossref_primary_10_1046_j_1365_2125_2003_02033_x crossref_primary_10_1007_BF00637732 crossref_primary_10_1007_BF03190117 crossref_primary_10_1111_j_1365_2125_1989_tb03502_x crossref_primary_10_1016_0006_2952_90_90283_Q crossref_primary_10_1007_BF00558224 crossref_primary_10_1016_0304_3959_93_90229_I crossref_primary_10_1111_j_1600_0773_1987_tb01758_x crossref_primary_10_1016_S0009_9236_96_90109_5 crossref_primary_10_1111_j_1440_1746_1988_tb00793_x crossref_primary_10_1007_BF00626372 crossref_primary_10_1111_j_1472_8206_1991_tb00713_x crossref_primary_10_1111_j_1365_2125_1989_tb05362_x crossref_primary_10_1111_j_1600_0447_1988_tb08572_x crossref_primary_10_1016_0378_4347_94_00259_2 crossref_primary_10_1515_dmdi_2014_0029 |
| Cites_doi | 10.1056/NEJM198212163072505 10.1111/j.1600-0773.1985.tb00058.x 10.2165/00003088-198005020-00003 10.1111/j.1365-2125.1985.tb02651.x 10.1016/0024-3205(83)90315-6 10.1016/0024-3205(84)90332-1 10.1136/jmg.17.2.102 10.1007/BF00541938 10.1038/clpt.1982.4 10.1111/j.1365-2125.1985.tb02723.x 10.1007/BF03189547 10.1007/BF00615971 10.1111/j.1365-2125.1984.tb02403.x 10.1038/clpt.1984.256 10.1007/BF00635712 10.1016/0006-2952(85)90533-7 10.2165/00003495-198529040-00003 10.1038/clpt.1984.138 |
| ContentType | Journal Article |
| Copyright | 1986 The British Pharmacological Society 1987 INIST-CNRS |
| Copyright_xml | – notice: 1986 The British Pharmacological Society – notice: 1987 INIST-CNRS |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
| DOI | 10.1111/j.1365-2125.1986.tb05250.x |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
| DatabaseTitleList | MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1365-2125 |
| EndPage | 197 |
| ExternalDocumentID | 10_1111_j_1365_2125_1986_tb05250_x 3756067 7857902 BCP5250 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1OC 23N 24P 2WC 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABOCM ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACFBH ACGFO ACGFS ACGOF ACMXC ACPOU ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFZJQ AHBTC AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOIJS ATUGU AZBYB AZVAB BAFTC BAWUL BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EBS EJD EMOBN ESX EX3 F00 F01 F04 F5P FIJ FUBAC G-S G.N GODZA GX1 H.X HF~ HGLYW HYE HZI HZ~ IHE IPNFZ IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LSO LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D Q.N Q11 QB0 R.K ROL RPM RX1 SUPJJ TEORI TR2 UB1 V8K W8V W99 WBKPD WHWMO WIH WIJ WIK WIN WOHZO WOW WQJ WRC WVDHM WXI WXSBR X7M XG1 YFH YOC YUY ZGI ZXP ZZTAW ~IA ~WT 08R AAJUZ AAPBV AAUGY AAVGM ABCVL ABHUG ABPTK ABWRO ACXME ADAWD ADDAD AFVGU AGJLS AKALU IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 5PM |
| ID | FETCH-LOGICAL-c5060-6e1941a163f76376e224f6ab60ca039896baabf84eaf256ce49ad9b3705be4743 |
| IEDL.DBID | RPM |
| ISSN | 0306-5251 |
| IngestDate | Tue Sep 17 21:19:43 EDT 2024 Fri Aug 23 01:27:44 EDT 2024 Sat Sep 28 08:38:49 EDT 2024 Sun Oct 29 17:10:06 EDT 2023 Sat Aug 24 01:17:28 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Human Cardiovascular disease Pharmacogenetics Pharmacokinetics Antiarrhythmia agent Polymorphism |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5060-6e1941a163f76376e224f6ab60ca039896baabf84eaf256ce49ad9b3705be4743 |
| OpenAccessLink | https://europepmc.org/articles/pmc1401116?pdf=render |
| PMID | 3756067 |
| PageCount | 4 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_1401116 crossref_primary_10_1111_j_1365_2125_1986_tb05250_x pubmed_primary_3756067 pascalfrancis_primary_7857902 wiley_primary_10_1111_j_1365_2125_1986_tb05250_x_BCP5250 |
| PublicationCentury | 1900 |
| PublicationDate | August 1986 |
| PublicationDateYYYYMMDD | 1986-08-01 |
| PublicationDate_xml | – month: 08 year: 1986 text: August 1986 |
| PublicationDecade | 1980 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: London – name: England |
| PublicationTitle | British journal of clinical pharmacology |
| PublicationTitleAlternate | Br J Clin Pharmacol |
| PublicationYear | 1986 |
| Publisher | Blackwell Publishing Ltd Blackwell Science |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Blackwell Science |
| References | 1980; 17 1985; 19 1985; 28 1985; 29 1984; 36 1984; 26 1982; 307 1984; 17 1982; 31 1984; 34 1980; 5 1983; 32 1982; 7 1986; 29 1985; 34 1985; 57 1983; 23 Boobis A. R. (e_1_2_1_2_1) 1983; 23 e_1_2_1_7_1 e_1_2_1_8_1 e_1_2_1_20_1 e_1_2_1_5_1 e_1_2_1_6_1 e_1_2_1_3_1 e_1_2_1_12_1 e_1_2_1_4_1 e_1_2_1_13_1 e_1_2_1_10_1 e_1_2_1_11_1 e_1_2_1_16_1 e_1_2_1_17_1 e_1_2_1_14_1 e_1_2_1_15_1 e_1_2_1_9_1 e_1_2_1_18_1 e_1_2_1_19_1 |
| References_xml | – volume: 29 start-page: 739 year: 1986 end-page: 741 article-title: Single‐dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers publication-title: Eur. J. clin. Pharmac. – volume: 19 start-page: 832 year: 1985 end-page: 835 article-title: Plasma concentrations of nortriptyline and its 10‐hydroxymetabolite in depressed patients—Relationship to the debrisoquine hydroxylation metabolic ratio publication-title: Br. J. clin. Pharmac. – volume: 34 start-page: 2501 year: 1985 end-page: 2505 article-title: Inhibition of desmethylimipramine 2‐hydroxylation by drugs in human liver microsomes publication-title: Biochem. Pharmac. – volume: 28 start-page: 79 year: 1985 end-page: 83 article-title: Interethnic difference in sparteine oxidation among Ghanaians and Germans publication-title: Eur. J. clin. Pharmac. – volume: 17 start-page: 679 year: 1984 end-page: 685 article-title: The relationship between debrisoquine oxidation phenotype and the pharmacokinetics and pharmacodynamics of propranolol publication-title: Br. J. clin. Pharmac. – volume: 36 start-page: 773 year: 1984 end-page: 780 article-title: Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism publication-title: Clin. Pharmac Ther. – volume: 23 start-page: 474 year: 1983 end-page: 481 article-title: Substrate specificity of the form of cytochrome P‐450 catalyzing the 4‐hydroxylation of debrisoquine in man publication-title: Mol. Pharmac. – volume: 34 start-page: 73 year: 1984 end-page: 80 article-title: Competitive inhibition of sparteine oxidation in human liver by beta‐adrenoceptor antagonists and other cardiovascular drugs publication-title: Life Sci. – volume: 31 start-page: 23 year: 1982 end-page: 29 article-title: Sparteine metabolism in Canadian Caucasians publication-title: Clin. Pharmac. Ther. – volume: 57 start-page: 357 year: 1985 end-page: 360 article-title: Sparteine oxidation polymorphism in Denmark publication-title: Acta Pharmac. Tox. – volume: 32 start-page: 795 year: 1983 end-page: 800 article-title: Inhibition of sparteine oxidation in human liver by tricyclic antidepressants and other drugs publication-title: Life Sci. – volume: 307 start-page: 1558 year: 1982 end-page: 1560 article-title: Oxidation phenotype—A major determinant of metoprolol metabolism and response publication-title: New Engl. J. Med. – volume: 36 start-page: 51 year: 1984 end-page: 56 article-title: Polymorphic ability to metabolize propranolol alters 4‐hydroxypropranolol levels but not beta‐blockade publication-title: Clin. Pharmac. Ther. – volume: 7 start-page: 73 year: 1982 end-page: 77 article-title: The genetic control of bufuralol metabolism in man publication-title: Eur. J. Drug. Metab. Pharmacokin. – volume: 29 start-page: 342 year: 1985 end-page: 375 article-title: Genetically determined variability in acetylation and oxidation: Therapeutic implications publication-title: Drugs – volume: 17 start-page: 102 year: 1980 end-page: 105 article-title: A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population publication-title: J. med. Genet. – volume: 19 start-page: 329 year: 1985 end-page: 333 article-title: Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics publication-title: Br. J. clin. Pharmac. – volume: 5 start-page: 150 year: 1980 end-page: 168 article-title: Clinical pharmacokinetics of quinidine publication-title: Clin. Pharmacokin. – volume: 26 start-page: 753 year: 1984 end-page: 759 article-title: Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man publication-title: Eur. J. clin. Pharmac. – volume: 23 start-page: 474 year: 1983 ident: e_1_2_1_2_1 article-title: Substrate specificity of the form of cytochrome P‐450 catalyzing the 4‐hydroxylation of debrisoquine in man publication-title: Mol. Pharmac. contributor: fullname: Boobis A. R. – ident: e_1_2_1_11_1 doi: 10.1056/NEJM198212163072505 – ident: e_1_2_1_3_1 doi: 10.1111/j.1600-0773.1985.tb00058.x – ident: e_1_2_1_14_1 doi: 10.2165/00003088-198005020-00003 – ident: e_1_2_1_12_1 doi: 10.1111/j.1365-2125.1985.tb02651.x – ident: e_1_2_1_15_1 doi: 10.1016/0024-3205(83)90315-6 – ident: e_1_2_1_16_1 doi: 10.1016/0024-3205(84)90332-1 – ident: e_1_2_1_7_1 doi: 10.1136/jmg.17.2.102 – ident: e_1_2_1_8_1 doi: 10.1007/BF00541938 – ident: e_1_2_1_18_1 doi: 10.1038/clpt.1982.4 – ident: e_1_2_1_13_1 doi: 10.1111/j.1365-2125.1985.tb02723.x – ident: e_1_2_1_5_1 doi: 10.1007/BF03189547 – ident: e_1_2_1_9_1 doi: 10.1007/BF00615971 – ident: e_1_2_1_10_1 doi: 10.1111/j.1365-2125.1984.tb02403.x – ident: e_1_2_1_20_1 doi: 10.1038/clpt.1984.256 – ident: e_1_2_1_6_1 doi: 10.1007/BF00635712 – ident: e_1_2_1_19_1 doi: 10.1016/0006-2952(85)90533-7 – ident: e_1_2_1_4_1 doi: 10.2165/00003495-198529040-00003 – ident: e_1_2_1_17_1 doi: 10.1038/clpt.1984.138 |
| SSID | ssj0013165 |
| Score | 1.5013397 |
| Snippet | In eight patients a sparteine‐test was carried out immediately before and after 1 week of treatment with quinidine 600‐800 mg day‐1. Before treatment one... In eight patients a sparteine-test was carried out immediately before and after 1 week of treatment with quinidine 600-800 mg day-1. Before treatment one... |
| SourceID | pubmedcentral crossref pubmed pascalfrancis wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 194 |
| SubjectTerms | Adult Aged Aged, 80 and over Biological and medical sciences Female General pharmacology Humans Male Medical sciences Middle Aged Oxidation-Reduction Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Quinidine - adverse effects Quinidine - therapeutic use Sparteine - metabolism |
| Title | Sparteine oxidation is practically abolished in quinidine‐treated patients |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2125.1986.tb05250.x https://www.ncbi.nlm.nih.gov/pubmed/3756067 https://pubmed.ncbi.nlm.nih.gov/PMC1401116 |
| Volume | 22 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB50QRBEfGJ9kYN4srvttk2aoy6KD5QFFbyVJE2xsNbVVdj9907SdB_e9FYa-iDf0Pmm-fINwElBGWYJ3fW1CLt-jJTVR5i5L3SQs0SYrGE2J98_0Ovn-PYleVmCpNkLY0X7SpbtavDWrspXq60cvqlOoxPr9O97pigIQ9pZhmUM0KZEb5YOQts_0nBhrLKS0DmNOvmOFXVhUm9jsU3Nb1GzrGfcqFcihsnftpuf5ae1oRjhVBV1j4u5JPVbQDlPbG1mutqAdUcpyXn96puwpKstOO3XntSTM_I022I1OiOnpD9zq55sw-3j0Mg6kWyS93FZd1gi5Yi47VNiMJgQDBSrnc9JWZGP77IqMeNp34rU8aTzZh3twPPV5VPv2ncNFnxlfAV9qkMehwIpWYGfGUY1IlNQIWmgRBDxlFMphCzSWIsCqZHSMRc5lxELEqlj5B670KreK70HJMiDQFHjHq_yOKVcpiIScSEYV0KmVHkQNdOaDWsfjWyu_kBYMgNLZmDJHCzZ2IOjBQSml7I0YTzoerBbAzEdcCh6wBYQmo4bN-3FEQwy66rtgsqD1GL5h7fMLnp9c7T_74cewKq5ZS0sPITW1-e3PkKy8yWPkebf3B3bEP8Bigb8Cg |
| link.rule.ids | 230,315,730,783,787,888,27938,27939,53806,53808 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFL0aQwgkxPdEgIEf0J6W1GkSO36EiqmMdapEh_YW2Y4jIrqs0FZa-fVcO04_9jbeolj5cI6Te258fC7Ax4pxjBKmHxoZ98MUKWuIMItQGlryTNqoYRcnj87Z8CI9vcwu9yDr1sI40b5WddRMr6Km_um0lbMr3et0Yr3xaGCTgjhmvXtwH99XyrokvZs8iF0FScuGMc_KYu816gU8TtaFYT3CdJvZH6N2Ys_6UT9IOIZ_V3B-E6Eez-QcH1bVVrnYClO3JZTb1NbFppOn8KPrVStJ-RUtFyrSf28ZPt6528_giWer5FPb_Bz2TPMCjsat3fXqmEw2q7fmx-SIjDdG2KuXcPp9ZhWjyGPJ9U3dFm8i9Zz4lVlyOl0RHINOll-SuiG_l3VTYzA1odO_405v-zp_BRcnXyaDYehrN4TaWhaGzMQijSWyvQq_YJwZBL1iUjGqJU1ELpiSUlV5amSFrEubVMhSqITTTJkUac0B7DfXjXkNhJaUamaN6XWZ5kyoXCYyrSQXWqqc6QCSDq9i1lp0FFupDeJdWLwLi3fh8S5uAjjcgXZ9KM8zLmg_gIMW4XWDHx4B8B3o1-3WqHu3BYF0ht0euAByN0jucJfF58HYbr3574t-gIfDyeisOPt6_u0tPLKnb_WL72B_8WdpDpFTLdR79wb9AzO1HQY |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB1BEQgJ8VFaEaDgQ9VTk3U2iRMfYWFVSltFaitVXCLbcUTENg3srtTl1zN2nP3ojd6iOF_OczJvkuc3APsVSzFK6KGvRTj0Y6SsPsLMfaFpmSbCRA0zOfn0jB1dxsdXydVaqS8r2leyDprJddDUP622sr1Wg14nNshPRyYpCEM2aMtq8BAe4TNLsz5R738ghLaKpGHEmGslofMbdSIeK-3C0B5gys3Mx1Hzc894Uj-OUqQAtuj8Kko9a8UUb1jVVbpYC1V3ZZTr9NbGp_EL-NH3rJOl_ArmMxmov3dMH-_V9Zfw3LFW8qnb5BU80M02HOSd7fXikFysZnFND8kByVeG2IvXcHzeGuUo8llyc1t3RZxIPSVuhpaYTBYEx6KV55ekbsjved3UGFS1b3XwuNLZv0534HL89WJ05LsaDr4y1oU-0yGPQ4Gsr8I3Wco0gl8xIRlVgkY840wKIass1qJC9qV0zEXJZZTSROoY6c0ubDU3jX4DhJaUKmYM6lUZZ4zLTEQirkTKlZAZUx5EPWZF21l1FGspDmJeGMwLg3nhMC9uPdjbgHe5a5olKadDD3Y7lJcNboh4kG7Av2w3ht2bLQimNe524HmQ2YHyH1dZfB7lZuntvU_6EZ7kX8bFybez7-_gqTl6J2N8D1uzP3O9h9RqJj_Yh-gfMRMfhg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sparteine+oxidation+is+practically+abolished+in+quinidine-treated+patients&rft.jtitle=British+journal+of+clinical+pharmacology&rft.au=BRINN%2C+R&rft.au=BR%C3%98SEN%2C+K&rft.au=GRAM%2C+L.+F&rft.au=HAGHFELT%2C+T&rft.date=1986-08-01&rft.pub=Blackwell+Science&rft.issn=0306-5251&rft.eissn=1365-2125&rft.volume=22&rft.issue=2&rft.spage=194&rft.epage=197&rft_id=info:doi/10.1111%2Fj.1365-2125.1986.tb05250.x&rft.externalDBID=n%2Fa&rft.externalDocID=7857902 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0306-5251&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0306-5251&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0306-5251&client=summon |