Improving Dissolution Rate of Carbamazepine-Glutaric Acid Cocrystal Through Solubilization by Excess Coformer

• Published in: Pharmaceutical research Vol. 35; no. 1; pp. 4 - 7
• Main Authors: Yamashita, Hiroyuki, Sun, Changquan Calvin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2018; Springer; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Carbamazepine; Dissolution; Drug delivery; Fiber optics; Formulation and Manufacturing of Solid Dosage Forms; Hydrochloric acid; Intestine; Laboratories; Medical Law; pH effects; Pharmacology/Toxicology; Pharmacy; Potassium; Powder; Powders; Research Paper; Sodium; Solubility; Solubilization; Stainless steel; Viscosity; cocrystal; solubilization; dissolution; carbamazepine

Purpose The use of soluble cocrystals is a promising strategy for delivering poorly soluble drugs. However, precipitation of poorly soluble crystal form during dissolution hinders the successful tablet development of cocrystals. This work was aimed to understand the mechanisms for improving dissolut...