A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer - Kurmis, Alexis A.; Yang, Fei; Welch, Timothy R.; Nickols, Nicholas G.; Dervan, Peter B. (Cancer research (Chicago, Ill.), 2017)
Keywords: Androgen receptors; Androgens; Animals; Antagonists; Antifungal agents; Antitumor activity; Cell Line, Tumor; Deoxyribonucleic acid; DNA; Drug Resistance, Neoplasm - drug effects; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genomic analysis; Glucocorticoids; Humans; Imidazole; Imidazoles - administration & dosage; Male; Mice; Nylons - pharmacology; Phenylthiohydantoin - administration & dosage; Phenylthiohydantoin - analogs & derivatives; Prostate cancer; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Pyrroles - administration & dosage; Receptors, Androgen - drug effects; Receptors, Glucocorticoid - antagonists & inhibitors; Ribonucleic acid; RNA; Toxicity; Transcription; Xenograft Model Antitumor Assays; Xenografts