The rate of the founder Jewish mutations in BRCA1 and BRCA2 in prostate cancer patients in Israel

• Published in: British journal of cancer Vol. 83; no. 4; pp. 463 - 466
• Main Authors: VAZINA, A, BANIEL, J, LIVNE, P. M, FRIEDMAN, E, YAACOBI, Y, SHTRIKER, A, ENGELSTEIN, D, LEIBOVITZ, I, ZEHAVI, M, SIDI, A. A, RAMON, Y, TISCHLER, T
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.08.2000
• Subjects: Age; Aged; Aged, 80 and over; Alleles; Biological and medical sciences; BRCA2 gene; BRCA2 Protein; Breast cancer; Cancer research; Family medical history; Genes, BRCA1 - genetics; Genetic Predisposition to Disease - genetics; Germ-Line Mutation; Humans; Israel; Jewish people; Jews - genetics; Loss of Heterozygosity; Male; Medical research; Medical sciences; Middle Aged; Mutation; Neoplasm Proteins - genetics; Nephrology. Urinary tract diseases; Ovarian cancer; Prostate cancer; prostate carcinoma; Prostatic Neoplasms - genetics; Regular; Transcription Factors - genetics; Tumors of the urinary system; Urinary tract. Prostate gland; Urology; Asia; Israel; Human; Urinary system disease; Prostate disease; Malignant tumor; Hereditary; Ethnic group; Germ line; Predisposition; Genetics; Mutation; Male genital diseases; Jew; Prostate; Tumor suppressor gene

Inherited predisposition occurs in 5-10% of all prostate cancer (CaP) patients, but the genes involved in conferring genetic susceptibility remain largely unknown. Several lines of evidence indicate that germline mutations in BRCA1 and BRCA2 might be associated with an increased risk for CaP. Three...