Genetic characterization and transmission of the multidrug resistance gene cfr in fecal and environmental pathways on a chicken farm in China

• Published in: Poultry science Vol. 104; no. 6; p. 105079
• Main Authors: Feng, Yiming, Li, Tiantian, Zhao, Shiyun, Li, Xuexue, Zhai, Yajun, Yuan, Li, Liu, Jianhua, Hu, Gongzheng, He, Dandan, Pan, Yushan
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.06.2025; Elsevier
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; antibiotic resistance; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; cfr; Chicken; Chickens; China; digestion; Drug Resistance, Multiple, Bacterial - genetics; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - genetics; Farm environment; farms; Feces - microbiology; Gene Transfer, Horizontal; genetic variation; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - genetics; MICROBIOLOGY AND FOOD SAFETY; multiple drug resistance; Phylogeny; Plasmid; Plasmids; Poultry Diseases - epidemiology; Poultry Diseases - microbiology; Poultry Diseases - transmission; public health; resistance genes; Transmission; China; Farm environment; Plasmid; Chicken; cfr; Transmission

•Revealed the multidrug resistance and genetic diversity of cfr-positive strains.•The cfr gene was identified in five distinct genetic environments.•The cfr spreading through both clonal transmission and plasmid- and IS26-mediated horizontal gene transfer.•The selective pressure exerted by florfenic...