Amiloride: A review

• Published in: Journal of the renin-angiotensin-aldosterone system Vol. 21; no. 4; p. 1470320320975893
• Main Authors: Sun, Qianhui, Sever, Peter
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.10.2020; Hindawi Limited
• Subjects: Diuretics; Endocrine system; Hypertension; Liver cirrhosis; Original; Potassium; Sodium; natriuretic; Amiloride; diuretic; hypertension; review

Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics...