p53 Transcriptional Activity Is Mediated through the SRC1-interacting Domain of CBP/p300

• Published in: The Journal of biological chemistry Vol. 277; no. 11; pp. 9054 - 9061
• Main Authors: Livengood, Jill A., Scoggin, Kirsten E.S., Van Orden, Karen, McBryant, Steven J., Edayathumangalam, Rajeswari S., Laybourn, Paul J., Nyborg, Jennifer K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2002; American Society for Biochemistry and Molecular Biology
• Subjects: Binding Sites; Binding, Competitive; CBP protein; CBP/p300 protein; Cell Transformation, Neoplastic; Gene Products, tax - metabolism; Histone Acetyltransferases; Human T-lymphotropic virus 1; Humans; Jurkat Cells; Nuclear Proteins - chemistry; Nuclear Proteins - physiology; Nuclear Receptor Coactivator 1; p300 protein; Tax protein; Trans-Activators - chemistry; Trans-Activators - physiology; Transcription Factors - metabolism; Transcriptional Activation; Tumor Suppressor Protein p53 - chemistry; Tumor Suppressor Protein p53 - physiology

The tumor suppressor p53 recruits the cellular coactivator CBP/p300 to mediate the transcriptional activation of target genes. In this study, we identify a novel p53-interacting region in CBP/p300, which we call CR2, located near the carboxyl terminus. The 95-amino acid CR2 region (amino acids 2055–...