Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protec...

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Bibliographic Details
Published inNutrients Vol. 10; no. 10; p. 1553
Main Authors Xu, Xiao-Yu, Meng, Xiao, Li, Sha, Gan, Ren-You, Li, Ya, Li, Hua-Bin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 19.10.2018
MDPI
Subjects
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Bacteria
bioactive properties
Bioavailability
Biological activity
Cancer
Chronic illnesses
Clinical trials
cooking
Curcuma longa
curcumin
Curcumin - chemistry
Curcumin - pharmacology
Diabetes
Enzymes
Food
food industry
Free radicals
Functional Food
functional foods
Gene expression
human health
Humans
Influenza
ingredients
liver
Metabolism
Metabolites
Microbiota
neoplasms
nervous system
Nutrition
Oxidative stress
Review
Rodents
turmeric
China
antioxidant
molecular mechanisms
gut metabolism
anti-inflammatory
health benefits
anticancer
curcumin
Online AccessGet full text

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Abstract Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.
AbstractList Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.
Curcumin is a principal curcuminoid of turmeric ( ), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.
Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.
Curcumin is a principal curcuminoid of turmeric ( Curcuma longa ), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent studies have demonstrated that curcumin has a variety of biological activities and pharmacological performances, providing protection and promotion of human health. In addition to presenting an overview of the gut metabolism of curcumin, this paper reviews the current research progress on its versatile bioactivity, such as antioxidant, anti-inflammatory, and immune-regulatory activities, and also intensively discusses its health benefits, including the protective or preventive effects on cancers and diabetes, as well as the liver, nervous system, and cardiovascular systems, highlighting the potential molecular mechanisms. Besides, the beneficial effects of curcumin on human are further stated based on clinical trials. Considering that there is still a debate on the beneficial effects of curcumin, we also discuss related challenges and prospects. Overall, curcumin is a promising ingredient of novel functional foods, with protective efficacy in preventing certain diseases. We hope this comprehensive and updated review will be helpful for promoting human-based studies to facilitate its use in human health and diseases in the future.
Author Li, Sha
Xu, Xiao-Yu
Li, Hua-Bin
Gan, Ren-You
Li, Ya
Meng, Xiao
AuthorAffiliation 2 School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China; u3003781@connect.hku.hk
4 South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510006, China
1 Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China; xuxy53@mail2.sysu.edu.cn (X.-Y.X.); mengx7@mail2.sysu.edu.cn (X.M.); liya28@mail3.sysu.edu.cn (Y.L.)
3 Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
AuthorAffiliation_xml – name: 1 Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China; xuxy53@mail2.sysu.edu.cn (X.-Y.X.); mengx7@mail2.sysu.edu.cn (X.M.); liya28@mail3.sysu.edu.cn (Y.L.)
– name: 2 School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China; u3003781@connect.hku.hk
– name: 4 South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510006, China
– name: 3 Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Author_xml – sequence: 1
  givenname: Xiao-Yu
  surname: Xu
  fullname: Xu, Xiao-Yu
– sequence: 2
  givenname: Xiao
  surname: Meng
  fullname: Meng, Xiao
– sequence: 3
  givenname: Sha
  surname: Li
  fullname: Li, Sha
– sequence: 4
  givenname: Ren-You
  orcidid: 0000-0002-4162-1511
  surname: Gan
  fullname: Gan, Ren-You
– sequence: 5
  givenname: Ya
  surname: Li
  fullname: Li, Ya
– sequence: 6
  givenname: Hua-Bin
  orcidid: 0000-0003-2332-8554
  surname: Li
  fullname: Li, Hua-Bin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30347782$$D View this record in MEDLINE/PubMed
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molecular mechanisms
gut metabolism
anti-inflammatory
health benefits
anticancer
curcumin
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Snippet Curcumin is a principal curcuminoid of turmeric (Curcuma longa), which is commonly used as a spice in cooking and a yellow pigment in the food processing...
Curcumin is a principal curcuminoid of turmeric ( ), which is commonly used as a spice in cooking and a yellow pigment in the food processing industry. Recent...
Curcumin is a principal curcuminoid of turmeric ( Curcuma longa ), which is commonly used as a spice in cooking and a yellow pigment in the food processing...
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SubjectTerms Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Bacteria
bioactive properties
Bioavailability
Biological activity
Cancer
Chronic illnesses
Clinical trials
cooking
Curcuma longa
curcumin
Curcumin - chemistry
Curcumin - pharmacology
Diabetes
Enzymes
Food
food industry
Free radicals
Functional Food
functional foods
Gene expression
human health
Humans
Influenza
ingredients
liver
Metabolism
Metabolites
Microbiota
neoplasms
nervous system
Nutrition
Oxidative stress
Review
Rodents
turmeric
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Title Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives
URI https://www.ncbi.nlm.nih.gov/pubmed/30347782
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Volume 10
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