Impairment of Glucose Metabolism and Suppression of Stemness in MCF-7/SC Human Breast Cancer Stem Cells by Nootkatone

• Published in: Pharmaceutics Vol. 14; no. 5; p. 906
• Main Authors: Nguyen, Yen Thi-Kim, To, Ngoc Bao, Truong, Vi Nguyen-Phuong, Kim, Hee Young, Ediriweera, Meran Keshawa, Lim, Yoongho, Cho, Somi Kim
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.04.2022; MDPI
• Subjects: AMPK; Breast cancer; breast cancer stem cells; cancer metabolism; Cancer therapies; Cell culture; Chemotherapy; Energy; Glucose; glycolysis; Kinases; Metabolism; nootkatone; oxidative phosphorylation; Population; Radiation therapy; Software; Stem cells; Tumors; United States > US; cancer metabolism; AMPK; breast cancer stem cells; nootkatone; oxidative phosphorylation; glycolysis

Targeting cancer stem cell metabolism has emerged as a promising therapeutic strategy for cancer treatment. Breast cancer stem cells (BCSCs) exert distinct metabolism machinery, which plays a major role in radiation and multidrug resistance. Therefore, exploring the mechanisms involved in energy uti...