Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion

• Published in: Laboratory investigation Vol. 86; no. 12; pp. 1221 - 1232
• Main Authors: Zagzag, David, Lukyanov, Yevgeniy, Lan, Li, Ali, M Aktar, Esencay, Mine, Mendez, Olga, Yee, Herman, Voura, Evelyn B, Newcomb, Elizabeth W
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2006; Nature Publishing; Nature Publishing Group
• Subjects: Adult; Aged; Aged, 80 and over; angiogenesis; Biological and medical sciences; Biotechnology; Cell Line, Tumor; CXCR4; Female; Fundamental and applied biological sciences. Psychology; Glioblastoma - blood supply; Glioblastoma - metabolism; Glioblastoma - pathology; gliomas; Humans; hypoxia; Hypoxia - metabolism; Hypoxia-Inducible Factor 1 - metabolism; hypoxia-inducible factor-1; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; migration; Neoplasm Invasiveness - pathology; Neovascularization, Pathologic - metabolism; Receptors, CXCR4 - antagonists & inhibitors; Receptors, CXCR4 - metabolism; stromal cell-derived factor-1α; Up-Regulation; vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; hypoxia; stromal cell-derived factor-1α; angiogenesis; vascular endothelial growth factor; hypoxia-inducible factor-1; migration; CXCR4; gliomas; Biotechnology; Migration; Glioblastoma; Chemokine receptor; Malignant glioma; Angiogenesis; Clinical biology; Neovascularization; CXC chemokine; CXCR4 chemokine receptor; Biological receptor; Nervous system diseases; Oxygen; Malignant tumor; Invasion; stromal-derived factor-1α; Vascular endothelium growth factor; Central nervous system disease; Hypoxia; Transcription factor HIF1

Hypoxia and hypoxia-inducible factor-1 (HIF-1) play a critical role in glioblastoma multiforme (GBMs). CXCR4 is involved in angiogenesis and is upregulated by HIF-1α. CXCR4 is a chemokine receptor for stromal cell-derived factor-1 (SDF-1)α, also known as CXCL12. We hypothesized that CXCR4 would be u...