Structural and Functional Validation of a Full-Thickness Self-Assembled Skin Equivalent for Disease Modeling

• Published in: Pharmaceutics Vol. 14; no. 6; p. 1211
• Main Authors: Mok, Bo Ram, Shon, Su-Ji, Kim, A Ram, Simard-Bisson, Carolyne, Martel, Israël, Germain, Lucie, Kim, Dong Hyun, Shin, Jung U
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.06.2022; MDPI
• Subjects: 3D skin; Collagen; Digital cameras; Extracellular matrix; Fibroblasts; Medical research; Morphology; Psoriasis; psoriasis model; reconstructed skin; Scanning electron microscopy; self-assembly tissue engineering; Skin diseases; United Kingdom > UK; United States > US; Japan; psoriasis model; self-assembly tissue engineering; reconstructed skin; 3D skin

Recently, various types of in vitro-reconstructed 3D skin models have been developed for drug testing and disease modeling. Herein, we structurally and functionally validated a self-assembled reconstructed skin equivalent (RSE) and developed an IL-17a-induced in vitro psoriasis-like model using a se...