Context-Dependent Roles of Claudins in Tumorigenesis

• Published in: Frontiers in oncology Vol. 11; p. 676781
• Main Author: Li, Jian
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 20.07.2021
• Subjects: cancer; claudin; metastasis; Oncology; tight junction; tumor heterogeneity; tumorigenesis

The barrier and fence functions of the claudin protein family are fundamental to tissue integrity and human health. Increasing evidence has linked claudins to signal transduction and tumorigenesis. The expression of claudins is frequently dysregulated in the context of neoplastic transformation. Stu...