Self-rating scales assessing subjective well-being and distress correlate with rCBF in PTSD-sensitive regions

• Published in: Psychological medicine Vol. 41; no. 12; pp. 2549 - 2561
• Main Authors: Nardo, D., Högberg, G., Flumeri, F., Jacobsson, H., Larsson, S. A., Hällström, T., Pagani, M.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.12.2011
• Subjects: Accidents; Accidents - psychology; Adult; Adult and adolescent clinical studies; Anxiety disorders. Neuroses; Basal ganglia; Biological and medical sciences; Blood flow; Case-Control Studies; Cerebrovascular Circulation - physiology; Clinical assessment; Crime Victims - psychology; Female; Humans; Interview, Psychological; Male; Mapping; Medical sciences; Miscellaneous; Neuropsychology; Occupational psychology; Occupational stress; Post traumatic stress disorder; Posttraumatic stress disorder; Psychological distress; Psychology. Psychoanalysis. Psychiatry; Psychometrics; Psychopathology; Psychopathology. Psychiatry; Railroads; Ratings & rankings; Scripts; Self Report; Stress Disorders, Post-Traumatic - diagnosis; Stress Disorders, Post-Traumatic - physiopathology; Stress Disorders, Post-Traumatic - psychology; Subjective wellbeing; Tomography, Emission-Computed, Single-Photon; Traumatic incidents; Traumatic life events; Uptake; Well being; PTSD; rCBF; subjective distress; subjective well-being; Impact of Event Scale; SPECT; Well-Being Index; Radionuclide study; Regional blood flow; Evaluation; Questionnaire; Self evaluation; Evaluation scale; Subjective experience; Anxiety disorder; Psychometrics; Posttraumatic stress disorder; Single photon emission tomography; Photon; Stress; Psychological distress; Hemodynamics; Psychological well-being
• ISSN: 0033-2917; 1469-8978; 1469-8978
• DOI: 10.1017/S0033291711000912

The aim of this study was to investigate the distribution of the regional cerebral blood flow (rCBF) in occupational-related post-traumatic stress disorder (PTSD) subjects and to seek possible correlations between brain perfusion and self-rating scales (SRS) in order to cross-check their diagnostic value and to look for their neural correlates. A total of 13 traumatized underground and long-distance train drivers developing (S) and 17 not developing (NS) PTSD who had experienced a 'person under train' accident or who had been assaulted at work underwent clinical assessment and 99mTc-HMPAO SPECT imaging during autobiographical trauma scripts. Statistical parametric mapping was applied to analyse rCBF changes in S as compared with NS and to search for correlations between rCBF and the administered SRS scores, modelling age, months to SPECT and the ratio 'grey matter/intra-cranial volume' as nuisance variables. Significantly higher activity was observed during trauma script in left posterior and anterior insula, posterior cingulate, inferior parietal lobule, precuneus, caudate and putamen in PTSD subjects as compared with the trauma-exposed control group. Impact of Event Scale and World Health Organisation (10) Well-Being Index scores highly correlated with tracer uptake to a great extent in the same regions in which rCBF differences between S and NS were found. These findings support the involvement of insular, cingulate and parietal cortices (as well as the basal ganglia) in the pathogenesis of PTSD and in the processing of related subjective well-being and distress.