Diet modification and its influence on metabolic and related pathological alterations in the SHR/NDmcr-cp rat, an animal model of the metabolic syndrome - Kawai, Kouji; Sakairi, Tetsuya; Harada, Shuichi; Shinozuka, Junko; Ide, Mika; Sato, Hiroko; Tanaka, Masaharu; Toriumi, Wataru; Kume, Eisuke (Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2012)
Keywords: animal models; Animals; Biological and medical sciences; Blood Glucose; Blood Pressure - physiology; Body Weight - physiology; Diabetes. Impaired glucose tolerance; Diabetogenic diet; Diet; Disease Models, Animal; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; excretion; fatty liver; Fatty Liver - metabolism; Fatty Liver - pathology; genes; glucose; Glycated Hemoglobin A - analysis; Glycosuria; high fat diet; histopathology; Hyperglycemia - diet therapy; Hyperglycemia - metabolism; Hyperglycemia - pathology; hyperlipidemia; Hyperlipidemias - diet therapy; Hyperlipidemias - metabolism; Hyperlipidemias - pathology; hyperplasia; Hyperplasia - metabolism; Hyperplasia - pathology; hypertension; Hypertension - diet therapy; Hypertension - metabolism; Hypertension - pathology; insulin secretion; Investigative techniques, diagnostic techniques (general aspects); Islet hyperplasia; Islets of Langerhans - metabolism; Islets of Langerhans - pathology; Kidney - metabolism; Kidney - pathology; kidneys; leptin receptors; Male; Medical sciences; Metabolic diseases; Metabolic syndrome; Metabolic Syndrome - diet therapy; Metabolic Syndrome - metabolism; Metabolic Syndrome - pathology; Miscellaneous; noninsulin-dependent diabetes mellitus; nonsense mutation; obesity; Obesity - diet therapy; Obesity - metabolism; Obesity - pathology; Other metabolic disorders; pancreas; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Rats; Rats, Inbred SHR; Rats, Inbred WKY; SHR/NDmcr-cp; Type 2 diabetes; Type 2 diabetes; Diabetogenic diet; SHR/NDmcr-cp; Islet hyperplasia; Metabolic syndrome; Endocrinopathy; Modification; Animal model; Rat; Hyperplasia; Autoimmune disease; Cardiovascular disease; Endocrine pancreas; Immunopathology; Nutrition; Rodentia; Langerhans islet; Metabolic diseases; Metabolism; Feeding; Vertebrata; Anatomic pathology; Mammalia; Diet; Type 1 diabetes