Epigenetic Regulation of Kaposi’s Sarcoma-Associated Herpesvirus Latency

• Published in: Frontiers in microbiology Vol. 11; p. 850
• Main Authors: Campbell, Mel, Yang, Wan-Shan, Yeh, Wayne W., Kao, Chen-Hsuan, Chang, Pei-Ching
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 19.05.2020
• Subjects: DNA methylation; epigenetic; histone modification; Kaposi’s sarcoma-associated herpesvirus (KSHV); long non-coding RNAs (lncRNAs); Microbiology; post-translational modification (PTM)

Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus that infects humans and exhibits a biphasic life cycle consisting of latent and lytic phases. Following entry into host cells, the KSHV genome undergoes circularization and chromatinization into an extrachromosomal epi...