STOP Pain Project—Opioid Response in Pediatric Cancer Patients and Gene Polymorphisms of Cytokine Pathways

• Published in: Pharmaceutics Vol. 14; no. 3; p. 619
• Main Authors: Crescioli, Giada, Lombardi, Niccolò, Vagnoli, Laura, Bettiol, Alessandra, Giunti, Laura, Cetica, Valentina, Coniglio, Maria Luisa, Provenzano, Aldesia, Giglio, Sabrina, Bonaiuti, Roberto, Mugelli, Alessandro, Aricò, Maurizio, Messeri, Andrea, Vannacci, Alfredo, Maggini, Valentina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.03.2022; MDPI
• Subjects: Age; Body mass index; cancer; Cancer therapies; Cytokines; Disease; Drug dosages; Fentanyl; Genes; genetic polymorphisms; Haplotypes; Leukemia; Lung cancer; Metastasis; Morphine; Narcotics; Nervous system; opioid; Pain; Pediatrics; pharmacogenetics; Tumor necrosis factor-TNF; Tumors; North America; Europe; pain; children; opioid; cancer; cytokines; genetic polymorphisms; pharmacogenetics

Moderate to severe cancer pain treatment in children is based on the use of weak and strong opioids. Pharmacogenetics play a central role in developing personalized pain therapies, as well as avoiding treatment failure and/or intolerable adverse drug reactions. This observational study aimed to inve...