Total and Cancer Mortality After Supplementation With Vitamins and Minerals: Follow-up of the Linxian General Population Nutrition Intervention Trial

• Published in: JNCI : Journal of the National Cancer Institute Vol. 101; no. 7; pp. 507 - 518
• Main Authors: Qiao, You-Lin, Dawsey, Sanford M., Kamangar, Farin, Fan, Jin-Hu, Abnet, Christian C., Sun, Xiu-Di, Johnson, Laura Lee, Gail, Mitchell H., Dong, Zhi-Wei, Yu, Binbing, Mark, Steven D., Taylor, Philip R.
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 01.04.2009; Oxford Publishing Limited (England)
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; alpha-Tocopherol - administration & dosage; Antioxidants - administration & dosage; Ascorbic Acid - administration & dosage; beta Carotene - administration & dosage; Biological and medical sciences; Cancer; China - epidemiology; Clinical outcomes; Clinical trials; Confounding Factors, Epidemiologic; Dietary minerals; Dietary Supplements; Diterpenes; Epidemiology; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Malnutrition - complications; Medical sciences; Micronutrients - administration & dosage; Middle Aged; Molybdenum - administration & dosage; Mortality; Neoplasms - mortality; Neoplasms - prevention & control; Niacin - administration & dosage; Nutrition research; Odds Ratio; Oncology; Retinyl Esters; Riboflavin - administration & dosage; Risk Factors; Selenium - administration & dosage; Tropical medicine; Tumors; Vitamin A - administration & dosage; Vitamin A - analogs & derivatives; Vitamins; Vitamins - administration & dosage; Zinc Oxide - administration & dosage; Asia; China; Human; Nutrition; Mortality; Vitamin; α-Tocopherol; Malignant tumor; Antioxidant; Epidemiology; Feeding; Micronutrient; Cancerology; Diet; Follow up study; Clinical trial; Betacarotene; Supplementation; Selenium; Public health; Cancer

Background The General Population Nutrition Intervention Trial was a randomized primary esophageal and gastric cancer prevention trial conducted from 1985 to 1991, in which 29 584 adult participants in Linxian, China, were given daily vitamin and mineral supplements. Treatment with “factor D,” a com...