An injectable and active hydrogel induces mutually enhanced mild magnetic hyperthermia and ferroptosis

• Published in: Biomaterials Vol. 298; p. 122139
• Main Authors: Chen, Xiaobin, Wang, Hancheng, Shi, Jiayue, Chen, Zhiyong, Wang, Yaoben, Gu, Siyi, Fu, Ye, Huang, Jiale, Ding, Jiandong, Yu, Lin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2023
• Subjects: Animals; Cell Line, Tumor; Ferroptosis; Hydrogels; Hyperthermia, Induced - methods; Hysteresis loss; Magnetic hyperthermia therapy (MHT); Mice; Multiple hyperthermia; Nanoparticles; Neoplasms - therapy; Theranostics; Thermosensitive hydrogel; Hysteresis loss; Ferroptosis; Magnetic hyperthermia therapy (MHT); Theranostics; Thermosensitive hydrogel; Multiple hyperthermia

Magnetic hyperthermia therapy (MHT) is a promising new modality to deal with solid tumors, yet the low magnetic-heat conversion efficacy, magnetic resonance imaging (MRI) artifacts, easy leakage of magnetic nanoparticles, and thermal resistance are the main obstacles to expand its clinical applicati...