Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer

• Published in: Translational oncology Vol. 39; p. 101825
• Main Authors: Li, Junping, Hu, Hong, He, Jinping, Hu, Yuling, Liu, Manting, Cao, Bihui, Chen, Dongni, Ye, Xiaodie, Zhang, Jian, Zhang, Zhiru, Long, Wen, Lian, Hui, Chen, Deji, Chen, Likun, Yang, Lili, Zhang, Zhenfeng
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.01.2024; Neoplasia Press; Elsevier
• Subjects: Carboplatin; CDC7 inhibitor; Homologous recombination repair; Original Research; Ovarian cancer; Homologous recombination repair; CBP; DSB; PFI; OC; Carboplatin; CDC7 inhibitor; CDC7; HR; PFS; Ovarian cancer

•A CDC7 inhibitor XL413 effectively enhanced the chemotherapeutic effect of carboplatin.•Mechanistically, the CDC7 inhibitor XL413 increases the accumulation of chemotherapy-induced DNA damage by inhibiting homologous recombination repair activity and delaying the recovery of DNA double-strand break...