Ursolic Acid Inhibits Collagen Production and Promotes Collagen Degradation in Skin Dermal Fibroblasts: Potential Antifibrotic Effects

• Published in: Biomolecules (Basel, Switzerland) Vol. 15; no. 3; p. 365
• Main Authors: He, Tianyuan, Xiang, Yaping, Quan, Hehui, Liu, Yingchun, Guo, Chunfang, Quan, Taihao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.03.2025; MDPI
• Subjects: Activator protein 1; Animals; Antibodies; Antifibrotic Agents - pharmacology; Biopsy; Bleomycin; Cell culture; Cells, Cultured; Chronic diseases; Chronic illnesses; Collagen; Collagen - metabolism; Degradation; Enzymes; Ethylenediaminetetraacetic acid; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibrosis; Fibrosis - drug therapy; Homeostasis; Human subjects; Humans; Interstitial collagenase; Kinases; Liver cirrhosis; MAKP; MAP kinase; Matrix metalloproteinase; Matrix Metalloproteinase 1 - metabolism; Medical research; Metalloproteinase; Mice; MMP-1; Protein kinases; Proteins; Signal Transduction - drug effects; Skin; Skin - cytology; Skin - drug effects; Skin - metabolism; Skin - pathology; Smad protein; TGF-β/Smad; Transcription factors; Transforming Growth Factor beta - metabolism; Transforming growth factor-b; Transforming growth factors; Triterpenes - pharmacology; Ursolic Acid; California; United States; Massachusetts; Germany; St Louis Missouri; United States > US; TGF-β/Smad; MMP-1; collagen; MAKP; fibrosis; AP-1; ursolic acid

Tissue fibrosis, characterized by excessive collagen accumulation, leads to impaired organ function and is a hallmark of various chronic diseases. Fibroblasts play a central role in collagen production and deposition. This study examines the impact of ursolic acid, a pentacyclic triterpenoid compoun...