Highly Water-Soluble Solid Dispersions of Honokiol: Preparation, Solubility, and Bioavailability Studies and Anti-Tumor Activity Evaluation

• Published in: Pharmaceutics Vol. 11; no. 11; p. 573
• Main Authors: Wang, Li, Wu, Weiwei, Wang, Lingling, Wang, Lu, Zhao, Xiuhua
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.11.2019; MDPI
• Subjects: antitumor activity; Bioavailability; Drug delivery systems; Drugs; Ethanol; Fourier transforms; honokiol; Hydrogen bonds; Nanoparticles; Polyethylene glycol; Scanning electron microscopy; solid dispersion; solubility; Solvents; China; Japan; solubility; honokiol; antitumor activity; bioavailability; solid dispersion

Honokiol (HK), a well-tolerated natural product, has many multiple pharmacological activities. However, its poor water solubility and low bioavailability limit its clinical application and development. The aim of this research was to prepare the solid dispersion (SD) formulation of honokiol (HK) wit...