Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution

Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects...

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Published inNutrients Vol. 11; no. 8; p. 1741
Main Authors Bocedi, Alessio, Noce, Annalisa, Marrone, Giulia, Noce, Gianluca, Cattani, Giada, Gambardella, Giorgia, Di Lauro, Manuela, Di Daniele, Nicola, Ricci, Giorgio
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.07.2019
MDPI
Subjects
Animals
autoimmune diseases
behavior disorders
Biomarkers
Biomarkers - blood
biosensors
dialysis
Environmental Exposure - adverse effects
Environmental Monitoring - methods
Environmental Pollutants - adverse effects
erythrocytes
Erythrocytes - drug effects
Erythrocytes - enzymology
Glutathione
Glutathione S-Transferase pi - blood
Glutathione S-Transferase pi - genetics
glutathione transferase
Health Status
Health Status Indicators
Hemodialysis
Humans
kidney diseases
kidney transplant
Kidney transplants
kidneys
liver
medicine
monitoring
neoplasms
neurodegenerative diseases
oxidative stress
Oxidative Stress - drug effects
pathogenesis
patients
pollution
Predictive Value of Tests
Review
Risk Assessment
Risk Factors
tissues
toxicity
toxins
glutathione transferase
chronic kidney disease
neurodegenerative disease
liver disease
glutathione
environmental pollution
kidney transplantation
hemodialysis
cancer
biomarker
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Abstract Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amounts of toxins are present in the body. Here we review articles concerning the level of GST in chronic kidney disease patients, in maintenance hemodialysis patients and to assess dialysis adequacy. GST is also over-expressed in autoimmune disease like scleroderma, and in kidney transplant patients and it may be used to check the efficiency of transplanted kidneys. The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported. Promising applications of e-GST discussed in the present review are its use for monitoring human subjects living in polluted areas and mammals for veterinary purpose.
AbstractList Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amounts of toxins are present in the body. Here we review articles concerning the level of GST in chronic kidney disease patients, in maintenance hemodialysis patients and to assess dialysis adequacy. GST is also over-expressed in autoimmune disease like scleroderma, and in kidney transplant patients and it may be used to check the efficiency of transplanted kidneys. The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported. Promising applications of e-GST discussed in the present review are its use for monitoring human subjects living in polluted areas and mammals for veterinary purpose.
Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amounts of toxins are present in the body. Here we review articles concerning the level of GST in chronic kidney disease patients, in maintenance hemodialysis patients and to assess dialysis adequacy. GST is also over-expressed in autoimmune disease like scleroderma, and in kidney transplant patients and it may be used to check the efficiency of transplanted kidneys. The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported. Promising applications of e-GST discussed in the present review are its use for monitoring human subjects living in polluted areas and mammals for veterinary purpose.Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or by acting as a ligandin. This review collects studies that propose GSTP1-1 as a useful biomarker in different fields of application. The most relevant studies are focused on GSTP1-1 as a biosensor to detect blood toxicity in patients affected by kidney diseases. In fact, this detoxifying enzyme is over-expressed in erythrocytes when unusual amounts of toxins are present in the body. Here we review articles concerning the level of GST in chronic kidney disease patients, in maintenance hemodialysis patients and to assess dialysis adequacy. GST is also over-expressed in autoimmune disease like scleroderma, and in kidney transplant patients and it may be used to check the efficiency of transplanted kidneys. The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported. Promising applications of e-GST discussed in the present review are its use for monitoring human subjects living in polluted areas and mammals for veterinary purpose.
Author Marrone, Giulia
Gambardella, Giorgia
Noce, Annalisa
Cattani, Giada
Di Lauro, Manuela
Bocedi, Alessio
Noce, Gianluca
Di Daniele, Nicola
Ricci, Giorgio
AuthorAffiliation 1 Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
4 Section of Legal Medicine, Social Security and Forensic Toxicology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
2 UOC of Internal Medicine-Center of Hypertension and Nephrology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
3 PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
AuthorAffiliation_xml – name: 4 Section of Legal Medicine, Social Security and Forensic Toxicology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
– name: 2 UOC of Internal Medicine-Center of Hypertension and Nephrology, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
– name: 3 PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
– name: 1 Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31357662$$D View this record in MEDLINE/PubMed
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2019 by the authors. 2019
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ISSN 2072-6643
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Issue 8
Keywords glutathione transferase
chronic kidney disease
neurodegenerative disease
liver disease
glutathione
environmental pollution
kidney transplantation
hemodialysis
cancer
biomarker
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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content type line 14
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content type line 23
These authors equally contributed to the work.
ORCID 0000-0003-1310-3730
0000-0001-7671-0015
0000-0002-5854-2086
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Snippet Glutathione transferase P1-1 (GSTP1-1) is expressed in some human tissues and is abundant in mammalian erythrocytes (here termed e-GST). This enzyme is able to...
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SubjectTerms Animals
autoimmune diseases
behavior disorders
Biomarkers
Biomarkers - blood
biosensors
dialysis
Environmental Exposure - adverse effects
Environmental Monitoring - methods
Environmental Pollutants - adverse effects
erythrocytes
Erythrocytes - drug effects
Erythrocytes - enzymology
Glutathione
Glutathione S-Transferase pi - blood
Glutathione S-Transferase pi - genetics
glutathione transferase
Health Status
Health Status Indicators
Hemodialysis
Humans
kidney diseases
kidney transplant
Kidney transplants
kidneys
liver
medicine
monitoring
neoplasms
neurodegenerative diseases
oxidative stress
Oxidative Stress - drug effects
pathogenesis
patients
pollution
Predictive Value of Tests
Review
Risk Assessment
Risk Factors
tissues
toxicity
toxins
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Title Glutathione Transferase P1-1 an Enzyme Useful in Biomedicine and as Biomarker in Clinical Practice and in Environmental Pollution
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Volume 11
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