Varenicline improves cognitive impairment in a mouse model of mPFC ischemia: The possible roles of inflammation, apoptosis, and synaptic factors

• Published in: Brain research bulletin Vol. 181; pp. 36 - 45
• Main Authors: Seyedaghamiri, Fatemehsadat, Hosseini, Leila, Kazmi, Sareh, Mahmoudi, Javad, Shanehbandi, Dariush, Ebrahimi-Kalan, Abbas, Rahbarghazi, Reza, Sadigh-Eteghad, Saeed, Farhoudi, Mehdi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2022; Elsevier
• Subjects: Animals; Anxiety; Anxiety - drug therapy; Anxiety - etiology; Apoptosis - drug effects; Behavior, Animal - drug effects; Brain ischemia; Brain Ischemia - complications; Brain Ischemia - immunology; Brain Ischemia - metabolism; Brain Ischemia - physiopathology; Cognitive Dysfunction - drug therapy; Cognitive Dysfunction - immunology; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - physiopathology; Disease Models, Animal; Medial prefrontal cortex; Memory; Mice; Neuroinflammatory Diseases - drug therapy; Neuroinflammatory Diseases - immunology; Neuroinflammatory Diseases - metabolism; Neuroinflammatory Diseases - physiopathology; Nicotinic Agonists - administration & dosage; Nicotinic Agonists - pharmacology; Prefrontal Cortex - drug effects; Prefrontal Cortex - immunology; Prefrontal Cortex - metabolism; Prefrontal Cortex - physiopathology; Synapses - drug effects; Synapses - metabolism; Varenicline; Varenicline - administration & dosage; Varenicline - pharmacology; Brain ischemia; Medial prefrontal cortex; Anxiety; Varenicline; Memory
• ISSN: 0361-9230; 1873-2747; 1873-2747
• DOI: 10.1016/j.brainresbull.2022.01.010

Ischemia in the medial prefrontal cortex (mPFC) causes cognitive impairment in stroke cases. This study aimed to examine the effects of varenicline as α7 and α4β2 nicotine acetylcholine receptors (nAChRs) agonist, on cognitive impairment, inflammation, apoptosis, and synaptic dysfunction in mPFC isc...