Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies

• Published in: Nutrients Vol. 12; no. 10; p. 2907
• Main Authors: Gandhi, Gopalsamy Rajiv, Vasconcelos, Alan Bruno Silva, Wu, Ding-Tao, Li, Hua-Bin, Antony, Poovathumkal James, Li, Hang, Geng, Fang, Gurgel, Ricardo Queiroz, Narain, Narendra, Gan, Ren-You
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.09.2020; MDPI
• Subjects: Adipocytes; administrative management; Animals; Antidiabetics; antioxidant enzymes; Antioxidants; bioactive compounds; biomarkers; Cell cycle; Cholesterol; chronic diseases; Chronic illnesses; Citrus; Citrus - chemistry; Citrus fruits; Diabetes; Diabetes Mellitus - diet therapy; Diabetic neuropathy; Disaccharides; Disease; Flavanones; Flavones; Flavonoids; Flavonoids - chemistry; Flavonoids - therapeutic use; Glucose; glycemic control; glycemic effect; Glycosides; health promotion; hesperetin; Hesperidin - analogs & derivatives; Humans; in vivo studies; Inflammation; Inflammation - diet therapy; Insulin resistance; lipid composition; Lipids; Lipoproteins; Metabolism; Metabolites; naringenin; naringin; neohesperidin; nutrients; Oxidative stress; pathogenesis; Phytochemicals - chemistry; Phytochemicals - therapeutic use; plant-based foods; Polyphenols - therapeutic use; Propiophenones; quercetin; renal function; Review; rutin; signal transduction; Systematic review; polyphenols; flavonoids; inflammation; diabetes; citrus

The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects, especially antidiabetic effects. We systematically review th...