Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies

The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects, especially antidiabetic effects. We systematically review th...

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Bibliographic Details
Published inNutrients Vol. 12; no. 10; p. 2907
Main Authors Gandhi, Gopalsamy Rajiv, Vasconcelos, Alan Bruno Silva, Wu, Ding-Tao, Li, Hua-Bin, Antony, Poovathumkal James, Li, Hang, Geng, Fang, Gurgel, Ricardo Queiroz, Narain, Narendra, Gan, Ren-You
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.09.2020
MDPI
Subjects
Adipocytes
administrative management
Animals
Antidiabetics
antioxidant enzymes
Antioxidants
bioactive compounds
biomarkers
Cell cycle
Cholesterol
chronic diseases
Chronic illnesses
Citrus
Citrus - chemistry
Citrus fruits
Diabetes
Diabetes Mellitus - diet therapy
Diabetic neuropathy
Disaccharides
Disease
Flavanones
Flavones
Flavonoids
Flavonoids - chemistry
Flavonoids - therapeutic use
Glucose
glycemic control
glycemic effect
Glycosides
health promotion
hesperetin
Hesperidin - analogs & derivatives
Humans
in vivo studies
Inflammation
Inflammation - diet therapy
Insulin resistance
lipid composition
Lipids
Lipoproteins
Metabolism
Metabolites
naringenin
naringin
neohesperidin
nutrients
Oxidative stress
pathogenesis
Phytochemicals - chemistry
Phytochemicals - therapeutic use
plant-based foods
Polyphenols - therapeutic use
Propiophenones
quercetin
renal function
Review
rutin
signal transduction
Systematic review
polyphenols
flavonoids
inflammation
diabetes
citrus
Online AccessGet full text

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Abstract The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects, especially antidiabetic effects. We systematically review the potential antidiabetic action and molecular mechanisms of citrus flavonoids based on in vitro and in vivo studies. A search of the PubMed, EMBASE, Scopus, and Web of Science Core Collection databases for articles published since 2010 was carried out using the keywords citrus, flavonoid, and diabetes. All articles identified were analyzed, and data were extracted using a standardized form. The search identified 38 articles, which reported that 19 citrus flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, and xanthohumol, have antidiabetic potential. These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications. Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
AbstractList The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects, especially antidiabetic effects. We systematically review the potential antidiabetic action and molecular mechanisms of citrus flavonoids based on in vitro and in vivo studies. A search of the PubMed, EMBASE, Scopus, and Web of Science Core Collection databases for articles published since 2010 was carried out using the keywords citrus, flavonoid, and diabetes. All articles identified were analyzed, and data were extracted using a standardized form. The search identified 38 articles, which reported that 19 citrus flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, and xanthohumol, have antidiabetic potential. These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications. Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects, especially antidiabetic effects. We systematically review the potential antidiabetic action and molecular mechanisms of citrus flavonoids based on in vitro and in vivo studies. A search of the PubMed, EMBASE, Scopus, and Web of Science Core Collection databases for articles published since 2010 was carried out using the keywords citrus, flavonoid, and diabetes. All articles identified were analyzed, and data were extracted using a standardized form. The search identified 38 articles, which reported that 19 citrus flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, and xanthohumol, have antidiabetic potential. These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications. Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are the main bioactive compounds in citrus fruits, with multiple beneficial effects, especially antidiabetic effects. We systematically review the potential antidiabetic action and molecular mechanisms of citrus flavonoids based on in vitro and in vivo studies. A search of the PubMed, EMBASE, Scopus, and Web of Science Core Collection databases for articles published since 2010 was carried out using the keywords citrus, flavonoid, and diabetes. All articles identified were analyzed, and data were extracted using a standardized form. The search identified 38 articles, which reported that 19 citrus flavonoids, including 8-prenylnaringenin, cosmosiin, didymin, diosmin, hesperetin, hesperidin, isosiennsetin, naringenin, naringin, neohesperidin, nobiletin, poncirin, quercetin, rhoifolin, rutin, sineesytin, sudachitin, tangeretin, and xanthohumol, have antidiabetic potential. These flavonoids regulated biomarkers of glycemic control, lipid profiles, renal function, hepatic enzymes, and antioxidant enzymes, and modulated signaling pathways related to glucose uptake and insulin sensitivity that are involved in the pathogenesis of diabetes and its related complications. Citrus flavonoids, therefore, are promising antidiabetic candidates, while their antidiabetic effects remain to be verified in forthcoming human studies.
Author Li, Hang
Wu, Ding-Tao
Vasconcelos, Alan Bruno Silva
Geng, Fang
Gan, Ren-You
Gandhi, Gopalsamy Rajiv
Antony, Poovathumkal James
Narain, Narendra
Li, Hua-Bin
Gurgel, Ricardo Queiroz
AuthorAffiliation 2 Chengdu National Agricultural Science and Technology Center, Chengdu 600103, China
9 Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, Campus São Cristóvão, São Cristóvão, Sergipe 49.100-000, Brazil; narendra.narain@gmail.com
3 Postgraduate Program of Health Sciences (PPGCS), Federal University of Sergipe (UFS), Prof. João Cardoso Nascimento Campus, Aracaju, Sergipe 49060-108, Brazil; ricardoqgurgel@gmail.com
8 Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China; gengfang@cdu.edu.cn
1 Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences (CAAS), Chengdu 600103, China; egarajiv@gmail.com (G.R.G.); tiantsai@sina.com (H.L.)
6 Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 5100
AuthorAffiliation_xml – name: 1 Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences (CAAS), Chengdu 600103, China; egarajiv@gmail.com (G.R.G.); tiantsai@sina.com (H.L.)
– name: 4 Postgraduate Program of Physiological Sciences (PROCFIS), Federal University of Sergipe (UFS), Campus São Cristóvão, São Cristóvão, Sergipe 49100-000, Brazil; abs.vasconcelos@gmail.com
– name: 6 Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; lihuabin@mail.sysu.edu.cn
– name: 7 Department of Microbiology, St. Xavier’s College, Kathmandu 44600, Nepal; jamesantonysj@gmail.com
– name: 5 Institute of Food Processing and Safety, College of Food Science, Sichuan Agricultural University, Ya’an 625014, China; DT_Wu@sicau.edu.cn
– name: 8 Key Laboratory of Coarse Cereal Processing (Ministry of Agriculture and Rural Affairs), School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China; gengfang@cdu.edu.cn
– name: 3 Postgraduate Program of Health Sciences (PPGCS), Federal University of Sergipe (UFS), Prof. João Cardoso Nascimento Campus, Aracaju, Sergipe 49060-108, Brazil; ricardoqgurgel@gmail.com
– name: 2 Chengdu National Agricultural Science and Technology Center, Chengdu 600103, China
– name: 9 Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, Campus São Cristóvão, São Cristóvão, Sergipe 49.100-000, Brazil; narendra.narain@gmail.com
Author_xml – sequence: 1
  givenname: Gopalsamy Rajiv
  surname: Gandhi
  fullname: Gandhi, Gopalsamy Rajiv
– sequence: 2
  givenname: Alan Bruno Silva
  orcidid: 0000-0002-7481-2015
  surname: Vasconcelos
  fullname: Vasconcelos, Alan Bruno Silva
– sequence: 3
  givenname: Ding-Tao
  orcidid: 0000-0002-7896-1886
  surname: Wu
  fullname: Wu, Ding-Tao
– sequence: 4
  givenname: Hua-Bin
  orcidid: 0000-0003-2332-8554
  surname: Li
  fullname: Li, Hua-Bin
– sequence: 5
  givenname: Poovathumkal James
  surname: Antony
  fullname: Antony, Poovathumkal James
– sequence: 6
  givenname: Hang
  orcidid: 0000-0003-4681-8791
  surname: Li
  fullname: Li, Hang
– sequence: 7
  givenname: Fang
  orcidid: 0000-0002-8275-6770
  surname: Geng
  fullname: Geng, Fang
– sequence: 8
  givenname: Ricardo Queiroz
  orcidid: 0000-0001-9651-3713
  surname: Gurgel
  fullname: Gurgel, Ricardo Queiroz
– sequence: 9
  givenname: Narendra
  orcidid: 0000-0003-3913-5992
  surname: Narain
  fullname: Narain, Narendra
– sequence: 10
  givenname: Ren-You
  orcidid: 0000-0002-4162-1511
  surname: Gan
  fullname: Gan, Ren-You
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32977511$$D View this record in MEDLINE/PubMed
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SecondaryResourceType review_article
Snippet The consumption of plant-based food is important for health promotion, especially concerning the prevention and management of chronic diseases. Flavonoids are...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 2907
SubjectTerms Adipocytes
administrative management
Animals
Antidiabetics
antioxidant enzymes
Antioxidants
bioactive compounds
biomarkers
Cell cycle
Cholesterol
chronic diseases
Chronic illnesses
Citrus
Citrus - chemistry
Citrus fruits
Diabetes
Diabetes Mellitus - diet therapy
Diabetic neuropathy
Disaccharides
Disease
Flavanones
Flavones
Flavonoids
Flavonoids - chemistry
Flavonoids - therapeutic use
Glucose
glycemic control
glycemic effect
Glycosides
health promotion
hesperetin
Hesperidin - analogs & derivatives
Humans
in vivo studies
Inflammation
Inflammation - diet therapy
Insulin resistance
lipid composition
Lipids
Lipoproteins
Metabolism
Metabolites
naringenin
naringin
neohesperidin
nutrients
Oxidative stress
pathogenesis
Phytochemicals - chemistry
Phytochemicals - therapeutic use
plant-based foods
Polyphenols - therapeutic use
Propiophenones
quercetin
renal function
Review
rutin
signal transduction
Systematic review
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Title Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies
URI https://www.ncbi.nlm.nih.gov/pubmed/32977511
https://www.proquest.com/docview/2535402460
https://www.proquest.com/docview/2446662418
https://www.proquest.com/docview/2511175421
https://pubmed.ncbi.nlm.nih.gov/PMC7598193
Volume 12
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