GFAP at 50

Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament family of proteins, it has become a subject for study in fields as diverse as structural biology, cell biology, gene expressio...

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Bibliographic Details
Published inASN neuro Vol. 12; no. 1; p. 1759091420949680
Main Authors Messing, Albee, Brenner, Michael
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 2020
Sage Publications Ltd
Taylor & Francis
Subjects
Gene expression
Gene therapy
Glial fibrillary acidic protein
Medical research
Nervous system
Alexander disease
intermediate filament
astrocyte
GFAP
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Summary:Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament family of proteins, it has become a subject for study in fields as diverse as structural biology, cell biology, gene expression, basic neuroscience, clinical genetics and gene therapy. This review covers each of these areas, presenting an overview of current understanding and controversies regarding GFAP with the goal of stimulating continued study of this fascinating protein.
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ISSN:1759-0914
1759-0914
DOI:10.1177/1759091420949680