Preservation From Left Ventricular Remodeling by Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Use of Granulocyte-Colony–Stimulating Factor (FIRSTLINE-AMI)

• Published in: Circulation (New York, N.Y.) Vol. 112; no. 20; pp. 3097 - 3106
• Main Authors: Ince, Hüseyin, Petzsch, Michael, Kleine, Hans Dieter, Schmidt, Heike, Rehders, Tim, Körber, Thomas, Schümichen, Carl, Freund, Mathias, Nienaber, Christoph A.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 15.11.2005
• Subjects: Adult; Biological and medical sciences; Blood and lymphatic vessels; Blood vessels and receptors; Cardiology. Vascular system; Coronary Angiography; Coronary heart disease; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Fluorodeoxyglucose F18; Fundamental and applied biological sciences. Psychology; Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use; Heart; Hematopoietic Stem Cell Mobilization; Humans; Male; Medical sciences; Middle Aged; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - physiopathology; Myocardial Infarction - prevention & control; Myocardial Infarction - therapy; Patient Selection; Positron-Emission Tomography; Radiopharmaceuticals; Recurrence; Stem Cell Transplantation; Ventricular Remodeling - physiology; Vertebrates: cardiovascular system; Myocardial infarction; remodeling; Preservation; Stem cell; Cardiovascular disease; Instrumental dilatation; Glucose; Myocardial disease; Left ventricle; Granulocyte colony stimulating factor; cells; Heart disease; Revascularization; angioplasty

Background— Considering experimental evidence that stem cells enhance myocardial regeneration and granulocyte colony–stimulating factor (G-CSF) mediates mobilization of CD34+ mononuclear blood stem cells (MNC CD34+ ), we tested the impact of G-CSF integrated into primary percutaneous coronary interv...