Enzyme-Linked Immunosorbent Assays Using Novel Japanese Encephalitis Virus Antigen Improve the Accuracy of Clinical Diagnosis of Flavivirus Infections

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Published inClinical and Vaccine Immunology Vol. 15; no. 5; pp. 825 - 835
Main Authors Chiou, Shyan-Song, Crill, Wayne D., Chen, Li-Kuang, Chang, Gwong-Jen J.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.05.2008
American Society for Microbiology (ASM)
Subjects
Animals
Antibodies, Viral - blood
Antigens, Viral - immunology
Cercopithecus aethiops
Clinical Laboratory Immunology
COS Cells
Cricetinae
Cross Reactions
Encephalitis Virus, Japanese - immunology
Enzyme-Linked Immunosorbent Assay
Flavivirus
Flavivirus - classification
Flavivirus - immunology
Flavivirus Infections - diagnosis
Flavivirus Infections - epidemiology
Flavivirus Infections - immunology
Flavivirus Infections - virology
Humans
Immunoglobulin M - blood
Japanese encephalitis virus
Viral Envelope Proteins - immunology
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Abstract Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CVI About CVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 1556-6811 Online ISSN: 1556-679X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CVI .asm.org, visit: CVI       
AbstractList The cross-reactive antibodies induced by flavivirus infections confound serodiagnosis and pathogenesis, especially in secondary infections caused by antigenically closely related yet distinct flaviviruses. The envelope (E) glycoprotein fusion peptide contains immunodominant cross-reactive determinants. Using a recombinant Japanese encephalitis virus (JEV) premembrane and E expression plasmid producing JEV virus-like particles (VLPs), dramatic reductions in cross-reactivity were produced by the G106K-L107D (KD) double-mutant VLP against a panel of flavivirus murine monoclonal antibodies. Human serum panels from patients with recent flavivirus infections were analyzed to compare the accuracy of JEV wild-type (WT) and KD VLPs as serodiagnostic antigens in enzyme-linked immunosorbent assays. Statistical analysis demonstrated significant differences in assay performances for accurate determination of current JEV infections between WT and KD antigens by detecting immunoglobulin M antibodies at a serum dilution of 1:4,000 (likelihood ratios = 2.74 [WT] and 22 [KD]). The application and continued development of cross-reactivity-reduced antigens should improve both flavivirus infection serodiagnosis and estimates of disease burden.The cross-reactive antibodies induced by flavivirus infections confound serodiagnosis and pathogenesis, especially in secondary infections caused by antigenically closely related yet distinct flaviviruses. The envelope (E) glycoprotein fusion peptide contains immunodominant cross-reactive determinants. Using a recombinant Japanese encephalitis virus (JEV) premembrane and E expression plasmid producing JEV virus-like particles (VLPs), dramatic reductions in cross-reactivity were produced by the G106K-L107D (KD) double-mutant VLP against a panel of flavivirus murine monoclonal antibodies. Human serum panels from patients with recent flavivirus infections were analyzed to compare the accuracy of JEV wild-type (WT) and KD VLPs as serodiagnostic antigens in enzyme-linked immunosorbent assays. Statistical analysis demonstrated significant differences in assay performances for accurate determination of current JEV infections between WT and KD antigens by detecting immunoglobulin M antibodies at a serum dilution of 1:4,000 (likelihood ratios = 2.74 [WT] and 22 [KD]). The application and continued development of cross-reactivity-reduced antigens should improve both flavivirus infection serodiagnosis and estimates of disease burden.
The cross-reactive antibodies induced by flavivirus infections confound serodiagnosis and pathogenesis, especially in secondary infections caused by antigenically closely related yet distinct flaviviruses. The envelope (E) glycoprotein fusion peptide contains immunodominant cross-reactive determinants. Using a recombinant Japanese encephalitis virus (JEV) premembrane and E expression plasmid producing JEV virus-like particles (VLPs), dramatic reductions in cross-reactivity were produced by the G106K-L107D (KD) double-mutant VLP against a panel of flavivirus murine monoclonal antibodies. Human serum panels from patients with recent flavivirus infections were analyzed to compare the accuracy of JEV wild-type (WT) and KD VLPs as serodiagnostic antigens in enzyme-linked immunosorbent assays. Statistical analysis demonstrated significant differences in assay performances for accurate determination of current JEV infections between WT and KD antigens by detecting immunoglobulin M antibodies at a serum dilution of 1:4,000 (likelihood ratios = 2.74 [WT] and 22 [KD]). The application and continued development of cross-reactivity-reduced antigens should improve both flavivirus infection serodiagnosis and estimates of disease burden.
Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CVI About CVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 1556-6811 Online ISSN: 1556-679X Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CVI .asm.org, visit: CVI       
Author Shyan-Song Chiou
Li-Kuang Chen
Wayne D. Crill
Gwong-Jen J. Chang
AuthorAffiliation Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan, Republic of China, 1 Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado, 2 College of Medicine, Tzu Chi University, Hualien, Taiwan, Republic of China 3
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  surname: Chang
  fullname: Chang, Gwong-Jen J.
  organization: Graduate Institute of Veterinary Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan, Republic of China, Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado, College of Medicine, Tzu Chi University, Hualien, Taiwan, Republic of China
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Corresponding author. Mailing address: Division of Vector-Borne Infectious Diseases, 3150 Rampart Road, CDC-Foothills Campus, Fort Collins, CO 80521. Phone: (970) 221-6497. Fax: (970) 226-3599. E-mail: gxc7@cdc.gov
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The cross-reactive antibodies induced by flavivirus infections confound serodiagnosis and pathogenesis, especially in secondary infections caused by...
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SubjectTerms Animals
Antibodies, Viral - blood
Antigens, Viral - immunology
Cercopithecus aethiops
Clinical Laboratory Immunology
COS Cells
Cricetinae
Cross Reactions
Encephalitis Virus, Japanese - immunology
Enzyme-Linked Immunosorbent Assay
Flavivirus
Flavivirus - classification
Flavivirus - immunology
Flavivirus Infections - diagnosis
Flavivirus Infections - epidemiology
Flavivirus Infections - immunology
Flavivirus Infections - virology
Humans
Immunoglobulin M - blood
Japanese encephalitis virus
Viral Envelope Proteins - immunology
Title Enzyme-Linked Immunosorbent Assays Using Novel Japanese Encephalitis Virus Antigen Improve the Accuracy of Clinical Diagnosis of Flavivirus Infections
URI http://cvi.asm.org/content/15/5/825.abstract
https://www.ncbi.nlm.nih.gov/pubmed/18337381
https://www.proquest.com/docview/21498045
https://www.proquest.com/docview/69183207
https://pubmed.ncbi.nlm.nih.gov/PMC2394851
Volume 15
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