MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia

► The expression of c-Kit was subject to post-transcriptional regulation by miR-193b. ► MiR-193b was down-regulated in AML cells and inversely correlated with c-Kit levels. ► Restoration of miR-193b in AML cells reduced c-Kit levels and inhibited cell growth. Mutations and/or overexpression of c-Kit...

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Published in	Leukemia research Vol. 35; no. 9; pp. 1226 - 1232
Main Authors	Gao, Xiao-ning, Lin, Ji, Gao, Li, Li, Yong-hui, Wang, Li-li, Yu, Li
Format	Journal Article
Language	English
Published	England Elsevier Ltd 01.09.2011
Subjects	Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over c-Kit Cell Proliferation Cells, Cultured Down-Regulation - genetics Female Gene Expression Regulation, Leukemic Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Male MicroRNA MicroRNAs - genetics MicroRNAs - physiology Middle Aged miR-193b Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Young Adult MicroRNA miR-193b c-Kit Acute myeloid leukemia
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ISSN	0145-2126 1873-5835 1873-5835
DOI	10.1016/j.leukres.2011.06.010

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Abstract	► The expression of c-Kit was subject to post-transcriptional regulation by miR-193b. ► MiR-193b was down-regulated in AML cells and inversely correlated with c-Kit levels. ► Restoration of miR-193b in AML cells reduced c-Kit levels and inhibited cell growth. Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML.
AbstractList	Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML.Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML. Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML. ► The expression of c-Kit was subject to post-transcriptional regulation by miR-193b. ► MiR-193b was down-regulated in AML cells and inversely correlated with c-Kit levels. ► Restoration of miR-193b in AML cells reduced c-Kit levels and inhibited cell growth. Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell proliferation and poor outcomes. We showed that c-Kit expression was subject to post-transcriptional regulation by microRNA (miRNA)-193b. Notably, miR-193b was significantly down-regulated in the examined AML cells and its levels were inversely correlated with c-Kit levels. Restoration of miR-193b expression in AML cells resulted in distinctly reduced c-Kit expression and inhibited cell growth. These data reveal a role for miR-193b dysregulation in myeloid leukemogenesis and the therapeutic promise of regulating miR-193b expression for c-Kit-positive AML. Highlights ► The expression of c-Kit was subject to post-transcriptional regulation by miR-193b. ► MiR-193b was down-regulated in AML cells and inversely correlated with c-Kit levels. ► Restoration of miR-193b in AML cells reduced c-Kit levels and inhibited cell growth.
Author	Gao, Xiao-ning Yu, Li Wang, Li-li Li, Yong-hui Lin, Ji Gao, Li
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Cites_doi	10.1038/leu.2009.104 10.1182/blood.V78.11.2962.2962 10.1016/S0092-8674(00)00114-8 10.1016/S0092-8674(04)00045-5 10.1182/blood.V95.2.726 10.1158/1535-7163.MCT-06-0071 10.1016/S0268-960X(03)00024-9 10.1038/nature02871 10.1073/pnas.0506216102 10.1073/pnas.0812413106 10.1182/blood-2010-09-191312 10.1073/pnas.0408831102 10.1182/blood-2005-04-1466 10.1056/NEJMoa074256 10.1016/j.ccr.2010.03.008 10.1182/blood-2005-09-3640 10.1006/meth.2001.1262 10.1016/j.leukres.2005.08.028 10.2353/ajpath.2010.091061 10.1158/0008-5472.CAN-05-2933 10.1200/JCO.20.6.1692 10.1016/j.ejca.2010.06.127 10.1038/onc.2009.245 10.1182/blood-2004-12-4617 10.1182/blood-2009-03-211938 10.1182/blood-2008-04-154310 10.1038/35077225 10.1080/10428190400007565 10.1200/JCO.2007.15.7461 10.1097/CEJ.0b013e328305a07a 10.1038/onc.2009.241
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References	Liu, Wu, Pang, Santhanam, Schwind, Wu (bib0100) 2010; 17 Xu, Liu, Fu, Li, Tie, Zhu (bib0135) 2010; 46 Marcucci, Mrózek, Radmacher, Garzon, Bloomfield (bib0080) 2011; 117 Leivonen, Mäkelä, Ostling, Kohonen, Haapa-Paananen, Kleivi (bib0160) 2009; 28 Growney, Clark, Adelsperger, Stone, Fabbro, Griffin (bib0050) 2005; 106 Felli, Fontana, Pelosi, Botta, Bonci, Facchiano (bib0095) 2005; 102 Wang, Zhou, Yin, Chen, Shi, Liang (bib0120) 2005; 102 Li, Yan, Shao (bib0155) 2009; 28 Reilly (bib0010) 2003; 17 Blume-Jensen, Hunter (bib0005) 2001; 411 Schnittger, Kohl, Haferlach, Kern, Hiddemann, Spiekermann (bib0040) 2006; 107 Heinrich, Maki, Corless, Antonescu, Harlow, Griffith (bib0060) 2008; 26 Yu, Rao, Wang, Tian, Lin, Liu (bib0150) 2006; 30 Heinrich, Blanke, Druker, Corless (bib0045) 2002; 20 Popovic, Riesbeck, Velu, Chaubey, Zhang, Achille (bib0090) 2009; 113 Livak, Schmittgen (bib0110) 2001; 25 Garzon, Heaphy, Havelange, Fabbri, Volinia, Tsao (bib0085) 2009; 114 Schlessinger (bib0015) 2000; 103 Ikeda, Kanakura, Tamaki, Kuriu, Kitayama, Ishikawa (bib0020) 1991; 78 Larizza, Magnani, Beghini (bib0115) 2005; 46 Cairoli, Beghini, Grillo, Nadali, Elice, Ripamonti (bib0030) 2006; 107 Ikezoe, Nishioka, Tasaka, Yang, Komatsu, Togitani (bib0145) 2006; 5 Beghini, Peterlongo, Ripamonti, Larizza, Cairoli, Morra (bib0025) 2000; 95 Bartel (bib0065) 2004; 116 Sambol, Ambrosini, Geha, Kennealey, Decarolis, O’connor (bib0140) 2006; 66 Marcucci, Radmacher, Maharry, Mrózek, Ruppert, Paschka (bib0075) 2008; 358 Gao, Lin, Li, Gao, Wang, Wang (bib0105) 2011; March Wu, Lin, Zhuang, Liang (bib0125) 2009; 18 Gajiwala, Wu, Christensen, Deshmukh, Diehl, DiNitto (bib0055) 2009; 106 Chen, Feilotter, Pare, Zhang, Pemberton, Garady (bib0130) 2010; 176 Jiao, Wu, Liang, Chen, Xiong, Chen (bib0035) 2009; 23 Ambros (bib0070) 2004; 431 Growney (10.1016/j.leukres.2011.06.010_bib0050) 2005; 106 Cairoli (10.1016/j.leukres.2011.06.010_bib0030) 2006; 107 Marcucci (10.1016/j.leukres.2011.06.010_bib0075) 2008; 358 Blume-Jensen (10.1016/j.leukres.2011.06.010_bib0005) 2001; 411 Wang (10.1016/j.leukres.2011.06.010_bib0120) 2005; 102 Wu (10.1016/j.leukres.2011.06.010_bib0125) 2009; 18 Yu (10.1016/j.leukres.2011.06.010_bib0150) 2006; 30 Chen (10.1016/j.leukres.2011.06.010_bib0130) 2010; 176 Ikeda (10.1016/j.leukres.2011.06.010_bib0020) 1991; 78 Larizza (10.1016/j.leukres.2011.06.010_bib0115) 2005; 46 Beghini (10.1016/j.leukres.2011.06.010_bib0025) 2000; 95 Sambol (10.1016/j.leukres.2011.06.010_bib0140) 2006; 66 Schnittger (10.1016/j.leukres.2011.06.010_bib0040) 2006; 107 Popovic (10.1016/j.leukres.2011.06.010_bib0090) 2009; 113 Heinrich (10.1016/j.leukres.2011.06.010_bib0060) 2008; 26 Ambros (10.1016/j.leukres.2011.06.010_bib0070) 2004; 431 Bartel (10.1016/j.leukres.2011.06.010_bib0065) 2004; 116 Felli (10.1016/j.leukres.2011.06.010_bib0095) 2005; 102 Xu (10.1016/j.leukres.2011.06.010_bib0135) 2010; 46 Li (10.1016/j.leukres.2011.06.010_bib0155) 2009; 28 Ikezoe (10.1016/j.leukres.2011.06.010_bib0145) 2006; 5 Livak (10.1016/j.leukres.2011.06.010_bib0110) 2001; 25 Jiao (10.1016/j.leukres.2011.06.010_bib0035) 2009; 23 Leivonen (10.1016/j.leukres.2011.06.010_bib0160) 2009; 28 Marcucci (10.1016/j.leukres.2011.06.010_bib0080) 2011; 117 Gajiwala (10.1016/j.leukres.2011.06.010_bib0055) 2009; 106 Schlessinger (10.1016/j.leukres.2011.06.010_bib0015) 2000; 103 Reilly (10.1016/j.leukres.2011.06.010_bib0010) 2003; 17 Gao (10.1016/j.leukres.2011.06.010_bib0105) 2011; March Heinrich (10.1016/j.leukres.2011.06.010_bib0045) 2002; 20 Liu (10.1016/j.leukres.2011.06.010_bib0100) 2010; 17 Garzon (10.1016/j.leukres.2011.06.010_bib0085) 2009; 114
References_xml	– volume: 95 start-page: 726 year: 2000 end-page: 727 ident: bib0025 article-title: C-kit mutations in core binding factor leukemias publication-title: Blood – volume: 102 start-page: 18081 year: 2005 end-page: 18086 ident: bib0095 article-title: MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation publication-title: Proc Natl Acad Sci USA – volume: 176 start-page: 2520 year: 2010 end-page: 2529 ident: bib0130 article-title: MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanoma publication-title: Am J Pathol – volume: March start-page: 14 year: 2011 ident: bib0105 article-title: MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia publication-title: Oncogene – volume: 17 start-page: 333 year: 2010 end-page: 347 ident: bib0100 article-title: Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia publication-title: Cancer Cell – volume: 18 start-page: 50 year: 2009 end-page: 55 ident: bib0125 article-title: Expression profile of mammalian microRNAs in endometrioid adenocarcinoma publication-title: Eur J Cancer Prev – volume: 411 start-page: 355 year: 2001 end-page: 365 ident: bib0005 article-title: Oncogenic kinase signaling publication-title: Nature – volume: 46 start-page: 2828 year: 2010 end-page: 2836 ident: bib0135 article-title: MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells publication-title: Eur J Cancer – volume: 358 start-page: 1919 year: 2008 end-page: 1928 ident: bib0075 article-title: MicroRNA expression in cytogenetically normal acute myeloid leukemia publication-title: N Engl J Med – volume: 25 start-page: 402 year: 2001 end-page: 408 ident: bib0110 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods – volume: 23 start-page: 1598 year: 2009 end-page: 1604 ident: bib0035 article-title: AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2 publication-title: Leukemia – volume: 103 start-page: 211 year: 2000 end-page: 225 ident: bib0015 article-title: Cell signaling by receptor tyrosine kinases publication-title: Cell – volume: 17 start-page: 241 year: 2003 end-page: 248 ident: bib0010 article-title: Receptor tyrosine kinases in normal and malignant haematopoiesis publication-title: Blood Rev – volume: 26 start-page: 5352 year: 2008 end-page: 5359 ident: bib0060 article-title: Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor publication-title: J Clin Oncol – volume: 102 start-page: 1104 year: 2005 end-page: 1109 ident: bib0120 article-title: AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec publication-title: Proc Natl Acad Sci USA – volume: 106 start-page: 721 year: 2005 end-page: 724 ident: bib0050 article-title: Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412 publication-title: Blood – volume: 5 start-page: 2522 year: 2006 end-page: 2530 ident: bib0145 article-title: The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling publication-title: Mol Cancer Ther – volume: 107 start-page: 3463 year: 2006 end-page: 3468 ident: bib0030 article-title: Prognostic impact of c-kit mutations in core binding factor leukemias: an Italian retrospective study publication-title: Blood – volume: 117 start-page: 1121 year: 2011 end-page: 1129 ident: bib0080 article-title: The prognostic and functional role of microRNAs in acute myeloid leukemia publication-title: Blood – volume: 28 start-page: 3926 year: 2009 end-page: 3936 ident: bib0160 article-title: Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines publication-title: Oncogene – volume: 116 start-page: 281 year: 2004 end-page: 297 ident: bib0065 article-title: MicroRNAs: genomics, biogenesis, mechanism, and function publication-title: Cell – volume: 28 start-page: 3937 year: 2009 end-page: 3948 ident: bib0155 article-title: Downregulation of miR-193b contributes to enhance urokinase-type plasminogen activator (uPA) expression and tumor progression and invasion in human breast cancer publication-title: Oncogene – volume: 113 start-page: 3314 year: 2009 end-page: 3322 ident: bib0090 article-title: Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization publication-title: Blood – volume: 30 start-page: 575 year: 2006 end-page: 582 ident: bib0150 article-title: The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level publication-title: Leuk Res – volume: 20 start-page: 1692 year: 2002 end-page: 1703 ident: bib0045 article-title: Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies publication-title: J Clin Oncol – volume: 431 start-page: 350 year: 2004 end-page: 355 ident: bib0070 article-title: The functions of animal microRNAs publication-title: Nature – volume: 107 start-page: 1791 year: 2006 end-page: 1799 ident: bib0040 article-title: KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival publication-title: Blood – volume: 106 start-page: 1542 year: 2009 end-page: 1547 ident: bib0055 article-title: KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients publication-title: Proc Natl Acad Sci USA – volume: 66 start-page: 5858 year: 2006 end-page: 5866 ident: bib0140 article-title: Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells publication-title: Cancer Res – volume: 114 start-page: 5331 year: 2009 end-page: 5341 ident: bib0085 article-title: MicroRNA 29b functions in acute myeloid leukemia publication-title: Blood – volume: 78 start-page: 2962 year: 1991 end-page: 2968 ident: bib0020 article-title: Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells publication-title: Blood – volume: 46 start-page: 247 year: 2005 end-page: 255 ident: bib0115 article-title: The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia publication-title: Leuk Lymphoma – volume: 23 start-page: 1598 year: 2009 ident: 10.1016/j.leukres.2011.06.010_bib0035 article-title: AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2 publication-title: Leukemia doi: 10.1038/leu.2009.104 – volume: 78 start-page: 2962 year: 1991 ident: 10.1016/j.leukres.2011.06.010_bib0020 article-title: Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells publication-title: Blood doi: 10.1182/blood.V78.11.2962.2962 – volume: 103 start-page: 211 year: 2000 ident: 10.1016/j.leukres.2011.06.010_bib0015 article-title: Cell signaling by receptor tyrosine kinases publication-title: Cell doi: 10.1016/S0092-8674(00)00114-8 – volume: 116 start-page: 281 year: 2004 ident: 10.1016/j.leukres.2011.06.010_bib0065 article-title: MicroRNAs: genomics, biogenesis, mechanism, and function publication-title: Cell doi: 10.1016/S0092-8674(04)00045-5 – volume: 95 start-page: 726 year: 2000 ident: 10.1016/j.leukres.2011.06.010_bib0025 article-title: C-kit mutations in core binding factor leukemias publication-title: Blood doi: 10.1182/blood.V95.2.726 – volume: 5 start-page: 2522 year: 2006 ident: 10.1016/j.leukres.2011.06.010_bib0145 article-title: The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-06-0071 – volume: 17 start-page: 241 year: 2003 ident: 10.1016/j.leukres.2011.06.010_bib0010 article-title: Receptor tyrosine kinases in normal and malignant haematopoiesis publication-title: Blood Rev doi: 10.1016/S0268-960X(03)00024-9 – volume: 431 start-page: 350 year: 2004 ident: 10.1016/j.leukres.2011.06.010_bib0070 article-title: The functions of animal microRNAs publication-title: Nature doi: 10.1038/nature02871 – volume: 102 start-page: 18081 year: 2005 ident: 10.1016/j.leukres.2011.06.010_bib0095 article-title: MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0506216102 – volume: 106 start-page: 1542 year: 2009 ident: 10.1016/j.leukres.2011.06.010_bib0055 article-title: KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0812413106 – volume: 117 start-page: 1121 year: 2011 ident: 10.1016/j.leukres.2011.06.010_bib0080 article-title: The prognostic and functional role of microRNAs in acute myeloid leukemia publication-title: Blood doi: 10.1182/blood-2010-09-191312 – volume: 102 start-page: 1104 year: 2005 ident: 10.1016/j.leukres.2011.06.010_bib0120 article-title: AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0408831102 – volume: 107 start-page: 1791 year: 2006 ident: 10.1016/j.leukres.2011.06.010_bib0040 article-title: KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival publication-title: Blood doi: 10.1182/blood-2005-04-1466 – volume: 358 start-page: 1919 year: 2008 ident: 10.1016/j.leukres.2011.06.010_bib0075 article-title: MicroRNA expression in cytogenetically normal acute myeloid leukemia publication-title: N Engl J Med doi: 10.1056/NEJMoa074256 – volume: 17 start-page: 333 year: 2010 ident: 10.1016/j.leukres.2011.06.010_bib0100 article-title: Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.03.008 – volume: 107 start-page: 3463 year: 2006 ident: 10.1016/j.leukres.2011.06.010_bib0030 article-title: Prognostic impact of c-kit mutations in core binding factor leukemias: an Italian retrospective study publication-title: Blood doi: 10.1182/blood-2005-09-3640 – volume: 25 start-page: 402 year: 2001 ident: 10.1016/j.leukres.2011.06.010_bib0110 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 30 start-page: 575 year: 2006 ident: 10.1016/j.leukres.2011.06.010_bib0150 article-title: The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level publication-title: Leuk Res doi: 10.1016/j.leukres.2005.08.028 – volume: 176 start-page: 2520 year: 2010 ident: 10.1016/j.leukres.2011.06.010_bib0130 article-title: MicroRNA-193b represses cell proliferation and regulates cyclin D1 in melanoma publication-title: Am J Pathol doi: 10.2353/ajpath.2010.091061 – volume: 66 start-page: 5858 year: 2006 ident: 10.1016/j.leukres.2011.06.010_bib0140 article-title: Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-2933 – volume: 20 start-page: 1692 year: 2002 ident: 10.1016/j.leukres.2011.06.010_bib0045 article-title: Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies publication-title: J Clin Oncol doi: 10.1200/JCO.20.6.1692 – volume: 46 start-page: 2828 year: 2010 ident: 10.1016/j.leukres.2011.06.010_bib0135 article-title: MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells publication-title: Eur J Cancer doi: 10.1016/j.ejca.2010.06.127 – volume: 28 start-page: 3937 year: 2009 ident: 10.1016/j.leukres.2011.06.010_bib0155 article-title: Downregulation of miR-193b contributes to enhance urokinase-type plasminogen activator (uPA) expression and tumor progression and invasion in human breast cancer publication-title: Oncogene doi: 10.1038/onc.2009.245 – volume: March start-page: 14 year: 2011 ident: 10.1016/j.leukres.2011.06.010_bib0105 article-title: MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia publication-title: Oncogene – volume: 106 start-page: 721 year: 2005 ident: 10.1016/j.leukres.2011.06.010_bib0050 article-title: Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412 publication-title: Blood doi: 10.1182/blood-2004-12-4617 – volume: 114 start-page: 5331 year: 2009 ident: 10.1016/j.leukres.2011.06.010_bib0085 article-title: MicroRNA 29b functions in acute myeloid leukemia publication-title: Blood doi: 10.1182/blood-2009-03-211938 – volume: 113 start-page: 3314 year: 2009 ident: 10.1016/j.leukres.2011.06.010_bib0090 article-title: Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization publication-title: Blood doi: 10.1182/blood-2008-04-154310 – volume: 411 start-page: 355 year: 2001 ident: 10.1016/j.leukres.2011.06.010_bib0005 article-title: Oncogenic kinase signaling publication-title: Nature doi: 10.1038/35077225 – volume: 46 start-page: 247 year: 2005 ident: 10.1016/j.leukres.2011.06.010_bib0115 article-title: The Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemia publication-title: Leuk Lymphoma doi: 10.1080/10428190400007565 – volume: 26 start-page: 5352 year: 2008 ident: 10.1016/j.leukres.2011.06.010_bib0060 article-title: Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor publication-title: J Clin Oncol doi: 10.1200/JCO.2007.15.7461 – volume: 18 start-page: 50 year: 2009 ident: 10.1016/j.leukres.2011.06.010_bib0125 article-title: Expression profile of mammalian microRNAs in endometrioid adenocarcinoma publication-title: Eur J Cancer Prev doi: 10.1097/CEJ.0b013e328305a07a – volume: 28 start-page: 3926 year: 2009 ident: 10.1016/j.leukres.2011.06.010_bib0160 article-title: Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines publication-title: Oncogene doi: 10.1038/onc.2009.241
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Snippet	► The expression of c-Kit was subject to post-transcriptional regulation by miR-193b. ► MiR-193b was down-regulated in AML cells and inversely correlated with... Highlights ► The expression of c-Kit was subject to post-transcriptional regulation by miR-193b. ► MiR-193b was down-regulated in AML cells and inversely... Mutations and/or overexpression of c-Kit proto-oncogene frequently occur in subsets of acute myeloid leukemia (AML) and contribute to abnormal cell...
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SubjectTerms	Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over c-Kit Cell Proliferation Cells, Cultured Down-Regulation - genetics Female Gene Expression Regulation, Leukemic Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Male MicroRNA MicroRNAs - genetics MicroRNAs - physiology Middle Aged miR-193b Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Young Adult
Title	MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia
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