Dysregulation of sterol regulatory element binding protein–1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling–3 and signal transducer and activator of transcription–1 signaling

• Published in: Metabolism, clinical and experimental Vol. 59; no. 4; pp. 587 - 598
• Main Authors: Elam, Marshall B., Yellaturu, Chandrahasa, Howell, George E., Deng, Xiong, Cowan, George S., Kumar, Poonam, Park, Edwards A., Hiler, M. Lloyd, Wilcox, Henry G., Hughes, Thomas A., Cook, George A., Raghow, Rajendra
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2010
• Subjects: Adult; Endocrinology & Metabolism; Fatty Acids - metabolism; Female; Gastric Bypass; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated - pharmacology; Insulin - pharmacology; Insulin Resistance; Lipoproteins, VLDL - biosynthesis; Liver - metabolism; Obesity, Morbid - metabolism; Polymerase Chain Reaction; Promoter Regions, Genetic; STAT1 Transcription Factor - physiology; STAT3 Transcription Factor - physiology; Stearoyl-CoA Desaturase - physiology; Sterol Regulatory Element Binding Protein 1 - genetics; Sulfonamides - pharmacology; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins - physiology; Triglycerides - biosynthesis; Weight Loss

We compared hepatic expression of genes that regulate lipid biosynthesis and metabolic signaling in liver biopsy specimens from women who were undergoing gastric bypass surgery (GBP) for morbid obesity with that in women undergoing ventral hernia repair who had experienced massive weight loss (MWL)...