Discovery and characterization of naturally occurring potent inhibitors of catechol- O -methyltransferase from herbal medicines

• Published in: RSC advances Vol. 11; no. 17; pp. 10385 - 10392
• Main Authors: Zhao, Dong-Fang, Fan, Yu-Fan, Wang, Fang-Yuan, Hou, Fan-Bin, Gonzalez, Frank J., Li, Shi-Yang, Wang, Ping, Xia, Yang-Liu, Ge, Guang-Bo, Yang, Ling
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 11.03.2021; The Royal Society of Chemistry
• Subjects: active sites; Affinity; Biomedical materials; Catechol; catechol O-methyltransferase; Chemistry; humans; Lead compounds; Liquid chromatography; Mass spectrometry; methylation; Neurotransmitters; plant extracts; therapeutics; Ultrafiltration; xenobiotics

Human catechol- O -methyltransferase (hCOMT) is considered a therapeutic target due to its crucial roles in the metabolic inactivation of endogenous neurotransmitters and xenobiotic drugs. There are nevertheless few safe and effective COMT inhibitors and there lacks a diversity in structure. To disc...