ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism

• Published in: Clinical cancer research Vol. 24; no. 13; pp. 3186 - 3196
• Main Authors: Liu, Mingyang, Yang, Jingxuan, Zhang, Yuqing, Zhou, Zhijun, Cui, Xiaobo, Zhang, Liyang, Fung, Kar-Ming, Zheng, Wei, Allard, Felicia D., Yee, Eric U., Ding, Kai, Wu, Huanwen, Liang, Zhiyong, Zheng, Lei, Fernandez-Zapico, Martin E., Li, Yi-Ping, Bronze, Michael S., Morris, Katherine T., Postier, Russell G., Houchen, Courtney W., Yang, Jing, Li, Min
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research Inc 01.07.2018
• Subjects: Animals; Biotechnology; Cancer; Cation Transport Proteins - metabolism; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Claudin-1 - genetics; Deactivation; Disease Models, Animal; Disease Progression; Epithelial-Mesenchymal Transition; Experimental design; Functional analysis; Gene expression; Gene Expression Regulation, Neoplastic; Genetic engineering; Heterografts; Humans; Immunohistochemistry; Inactivation; Invasiveness; Metastases; Metastasis; Mice; Models, Biological; Neoplasia; Neoplasm Staging; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Paxillin; Phosphorylation; Signal Transduction; Therapeutic applications; Transcription; Transcription, Genetic; Tumor cell lines; Tumors; Xenografts; Xenotransplantation; Zinc Finger E-box-Binding Homeobox 1 - metabolism; Zonula occludens-1 protein; Zonula Occludens-1 Protein - genetics

Purpose: ZIP4 is overexpressed in human pancreatic cancer and promotes tumor growth. However, little is known about the role of ZIP4 in advanced stages of this dismal neoplasm. Our goal is to study the underlying mechanism and define a novel signaling pathway controlled by ZIP4-modulating pancreatic...