Common substitution mutation F348Y of acetylcholinesterase gene contributes to organophosphate and carbamate resistance in Cimex lectularius and C. hemipterus

• Published in: Insect Biochemistry and Molecular Biology Vol. 138; p. 103637
• Main Authors: Komagata, Osamu, Kasai, Shinji, Itokawa, Kentaro, Minagawa, Keiko, Kazuma, Toru, Mizutani, Kiyoshi, Muto, Atsuhiko, Tanikawa, Tsutomu, Adachi, Masaya, Komatsu, Noriyuki, Tomita, Takashi
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.11.2021; Elsevier BV
• Subjects: Acetylcholinesterase; amino acid substitution; Animals; azamethiphos; Bedbugs; Carbamates; carbaryl; chlorpyrifos-methyl; Cimex; Cimex lectularius; dichlorvos; Enzyme inhibitor; Enzyme kinetics; Female; fenitrothion; genes; insect biochemistry; Insect Proteins; Insecticide Resistance; Insecticides; Japan; malaoxon; Male; molecular biology; mutants; Mutation; Organophosphates; paraoxon; Point mutation; propoxur; pyrethrins; Recombinant protein; Species Specificity; Insecticide resistance; Point mutation; Enzyme inhibitor; Cimex; Recombinant protein; Acetylcholinesterase; Enzyme kinetics

Bed bug control highly depends on insecticides with a limited number of modes of action, especially since the global prevalence of pyrethroid resistance. De facto insecticide options against bed bugs in Japan are acetylcholinesterase inhibitors (AChEis) that consist of organophosphates and carbamate...