Anti-inflammatory Polyketides from the Marine-Derived Fungus Eutypella scoparia

• Published in: Marine drugs Vol. 20; no. 8; p. 486
• Main Authors: Zhang, Ya-Hui, Du, Hui-Fang, Gao, Wen-Bin, Li, Wan, Cao, Fei, Wang, Chang-Yun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.07.2022; MDPI
• Subjects: absolute configuration; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; Ascomycota - chemistry; Carbon; Carbon radioisotopes; Circular dichroism; circular dichroism spectroscopy; Configurations; Dichroism; Eutypella; Eutypella scoparia; Fungi; Inflammation; Lipopolysaccharides; Macrophages; marine-derived fungus; Metabolites; Molecular Structure; Nitric oxide; NMR; Nuclear magnetic resonance; Planar structures; polyketide; Polyketides; Polyketides - chemistry; Two dimensional analysis; absolute configuration; polyketide; marine-derived fungus; Eutypella scoparia; anti-inflammatory activity
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md20080486

Three new polyketides, eutyketides A and B (1 and 2) and cytosporin X (3), along with four known compounds (4–7), were obtained from the marine-derived fungus Eutypella scoparia. The planar structures of 1 and 2 were elucidated by extensive HRMS and 1D and 2D NMR analyses. Their relative configurati...