Alcohol effects on hepatic lipid metabolism

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated...

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Bibliographic Details
Published inJournal of lipid research Vol. 61; no. 4; pp. 470 - 479
Main Authors Jeon, Sookyoung, Carr, Rotonya
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2020
The American Society for Biochemistry and Molecular Biology
Elsevier
Subjects
alcoholic liver disease
fatty acid oxidation
fatty acid uptake
lipid droplets
lipogenesis
Review
steatosis
alcoholic liver disease
lipogenesis
fatty acid oxidation
lipid droplets
fatty acid uptake
steatosis
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Abstract Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the development of later stages of ALD. This review explores the disturbances of alcohol-induced hepatic lipid metabolism through altered hepatic lipid uptake, de novo lipid synthesis, fatty acid oxidation, hepatic lipid export, and lipid droplet formation and catabolism. In addition, we review emerging data on the contributions of genetics and bioactive lipid metabolism in alcohol-induced hepatic lipid accumulation.
AbstractList Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the development of later stages of ALD. This review explores the disturbances of alcohol-induced hepatic lipid metabolism through altered hepatic lipid uptake, de novo lipid synthesis, fatty acid oxidation, hepatic lipid export, and lipid droplet formation and catabolism. In addition, we review emerging data on the contributions of genetics and bioactive lipid metabolism in alcohol-induced hepatic lipid accumulation.
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the development of later stages of ALD. This review explores the disturbances of alcohol-induced hepatic lipid metabolism through altered hepatic lipid uptake, de novo lipid synthesis, fatty acid oxidation, hepatic lipid export, and lipid droplet formation and catabolism. In addition, we review emerging data on the contributions of genetics and bioactive lipid metabolism in alcohol-induced hepatic lipid accumulation.Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the development of later stages of ALD. This review explores the disturbances of alcohol-induced hepatic lipid metabolism through altered hepatic lipid uptake, de novo lipid synthesis, fatty acid oxidation, hepatic lipid export, and lipid droplet formation and catabolism. In addition, we review emerging data on the contributions of genetics and bioactive lipid metabolism in alcohol-induced hepatic lipid accumulation.
Author Carr, Rotonya
Jeon, Sookyoung
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  givenname: Rotonya
  surname: Carr
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32029510$$D View this record in MEDLINE/PubMed
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ISSN 0022-2275
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Issue 4
Keywords alcoholic liver disease
lipogenesis
fatty acid oxidation
lipid droplets
fatty acid uptake
steatosis
Language English
License This is an open access article under the CC BY license.
http://creativecommons.org/licenses/by/4.0
https://www.elsevier.com/tdm/userlicense/1.0
Copyright © 2020 Jeon and Carr.
Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.
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OpenAccessLink https://doaj.org/article/1d549b8465a74139913be53573d0c8ca
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PublicationDate 2020-04-01
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PublicationTitle Journal of lipid research
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Snippet Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple...
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SubjectTerms alcoholic liver disease
fatty acid oxidation
fatty acid uptake
lipid droplets
lipogenesis
Review
steatosis
Title Alcohol effects on hepatic lipid metabolism
URI https://dx.doi.org/10.1194/jlr.R119000547
https://www.ncbi.nlm.nih.gov/pubmed/32029510
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