The depressive-like behaviors of chronic unpredictable mild stress-treated mice, ameliorated by Tibetan medicine Zuotai: involvement in the hypothalamic-pituitary-adrenal (HPA) axis pathway

• Published in: Neuropsychiatric disease and treatment Vol. 14; pp. 129 - 141
• Main Authors: Zhao, Jing, Niu, Cuiying, Wang, Jianv, Yang, Hongxia, Du, Yuzhi, Wei, Lixin, Li, Cen
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Antidepressants; Behavior; Body weight; Brain; Central nervous system; Chronic unpredictable mild stress (CUMS); Contamination; Corticosterone; Corticotropin; Corticotropin-releasing hormone; Depression; Depression (Mood disorder); Enzyme-linked immunosorbent assay; Gene expression; HgS; Hormones; HPA axis; Imipramine; Laboratories; Medical research; Medicine; Mental depression; Microscopy; Monoamines; Neurohormones; Original Research; Pituitary gland; Pituitary hormones; Steroids (Organic compounds); Stress response; Suicides & suicide attempts; Sulfur; Swimming; Thyroid gland; Tibetan medicine; Zuotai; United States > US; China; Germany; Zuotai; chronic unpredictable mild stress; HgS; Tibetan medicine; CUMS; HPA axis; depression

Zuotai, a famous Tibetan medicinal mixture containing metacinnabar, is traditionally used for the purpose of tranquilizing minds and soothing nerves. However, it still lacks substantial experimental data for it to be approved for use. This study was designed to assess the effects of Zuotai on depres...