Effect of Hydrogel Containing Achyrocline satureioides (Asteraceae) Extract-Loaded Nanoemulsions on Wound Healing Activity

(Lam.) DC extract-loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the first in vivo investigation of the wound healing activity of a hydrogel containing extract-loaded nanoemulsions. We prepared hydrogels by add...

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Published inPharmaceutics Vol. 14; no. 12; p. 2726
Main Authors Balestrin, Lucélia Albarello, Back, Patrícia Inês, Marques, Magno da Silva, Araújo, Gabriela de Moraes Soares, Carrasco, Mariana Corrêa Falkembach, Batista, Matheus Monteiro, Silveira, Tony, Rodrigues, Jamile Lima, Fachel, Flávia Nathiely Silveira, Koester, Leticia Scherer, Bassani, Valquiria Linck, Horn, Ana Paula, Dora, Cristiana Lima, Teixeira, Helder Ferreira
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.12.2022
MDPI
Subjects
Achyrocline satureioides
Animals
Ethanol
Flavonoids
healing activity
Herbal medicine
hydrogel
Hydrogels
Injuries
nanoemulsion
Nanoemulsions
Skin
Triglycerides
Wound healing
Brazil
United States > US
Rio de Janeiro Brazil
nanoemulsion
Achyrocline satureioides
hydrogel
healing activity
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Abstract (Lam.) DC extract-loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the first in vivo investigation of the wound healing activity of a hydrogel containing extract-loaded nanoemulsions. We prepared hydrogels by adding the gelling agent (Carbopol Ultrez) to extract-loaded nanoemulsions (~250 nm in diameter) obtained by spontaneous emulsification. The final flavonoid content in formulation was close to 1 mg/mL, as estimated by ultra-fast liquid chromatography. Permeation/retention studies using porcine ear skin showed that flavonoids reached deeper layers of pig ear skin when it was damaged (up to 3.2 µg/cm² in the dermis), but did not reach the Franz-type diffusion cell receptor fluid. For healing activity, we performed a dorsal wound model using Wistar rats, evaluating the lesion size, anti-inflammatory markers, oxidative damage, and histology. We found that extract-loaded formulations promoted wound healing by increasing angiogenesis by ~20%, reducing inflammation (tumor necrosis factor α) by ~35%, decreasing lipid damage, and improving the re-epithelialization process in lesions. In addition, there was an increase in the number of blood vessels and hair follicles for wounds treated with the formulation compared with the controls. Our findings indicate that the proposed formulation could be promising in the search for better quality healing and tissue reconstruction.
AbstractList Achyrocline satureioides (Lam.) DC extract–loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the first in vivo investigation of the wound healing activity of a hydrogel containing A. satureioides extract–loaded nanoemulsions. We prepared hydrogels by adding the gelling agent (Carbopol® Ultrez) to extract-loaded nanoemulsions (~250 nm in diameter) obtained by spontaneous emulsification. The final flavonoid content in formulation was close to 1 mg/mL, as estimated by ultra-fast liquid chromatography. Permeation/retention studies using porcine ear skin showed that flavonoids reached deeper layers of pig ear skin when it was damaged (up to 3.2 µg/cm² in the dermis), but did not reach the Franz-type diffusion cell receptor fluid. For healing activity, we performed a dorsal wound model using Wistar rats, evaluating the lesion size, anti-inflammatory markers, oxidative damage, and histology. We found that extract-loaded formulations promoted wound healing by increasing angiogenesis by ~20%, reducing inflammation (tumor necrosis factor α) by ~35%, decreasing lipid damage, and improving the re-epithelialization process in lesions. In addition, there was an increase in the number of blood vessels and hair follicles for wounds treated with the formulation compared with the controls. Our findings indicate that the proposed formulation could be promising in the search for better quality healing and tissue reconstruction.
Achyrocline satureioides (Lam.) DC extract–loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the first in vivo investigation of the wound healing activity of a hydrogel containing A. satureioides extract–loaded nanoemulsions. We prepared hydrogels by adding the gelling agent (Carbopol ® Ultrez) to extract-loaded nanoemulsions (~250 nm in diameter) obtained by spontaneous emulsification. The final flavonoid content in formulation was close to 1 mg/mL, as estimated by ultra-fast liquid chromatography. Permeation/retention studies using porcine ear skin showed that flavonoids reached deeper layers of pig ear skin when it was damaged (up to 3.2 µg/cm² in the dermis), but did not reach the Franz-type diffusion cell receptor fluid. For healing activity, we performed a dorsal wound model using Wistar rats, evaluating the lesion size, anti-inflammatory markers, oxidative damage, and histology. We found that extract-loaded formulations promoted wound healing by increasing angiogenesis by ~20%, reducing inflammation (tumor necrosis factor α) by ~35%, decreasing lipid damage, and improving the re-epithelialization process in lesions. In addition, there was an increase in the number of blood vessels and hair follicles for wounds treated with the formulation compared with the controls. Our findings indicate that the proposed formulation could be promising in the search for better quality healing and tissue reconstruction.
(Lam.) DC extract-loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the first in vivo investigation of the wound healing activity of a hydrogel containing extract-loaded nanoemulsions. We prepared hydrogels by adding the gelling agent (Carbopol Ultrez) to extract-loaded nanoemulsions (~250 nm in diameter) obtained by spontaneous emulsification. The final flavonoid content in formulation was close to 1 mg/mL, as estimated by ultra-fast liquid chromatography. Permeation/retention studies using porcine ear skin showed that flavonoids reached deeper layers of pig ear skin when it was damaged (up to 3.2 µg/cm² in the dermis), but did not reach the Franz-type diffusion cell receptor fluid. For healing activity, we performed a dorsal wound model using Wistar rats, evaluating the lesion size, anti-inflammatory markers, oxidative damage, and histology. We found that extract-loaded formulations promoted wound healing by increasing angiogenesis by ~20%, reducing inflammation (tumor necrosis factor α) by ~35%, decreasing lipid damage, and improving the re-epithelialization process in lesions. In addition, there was an increase in the number of blood vessels and hair follicles for wounds treated with the formulation compared with the controls. Our findings indicate that the proposed formulation could be promising in the search for better quality healing and tissue reconstruction.
Author Marques, Magno da Silva
Silveira, Tony
Rodrigues, Jamile Lima
Bassani, Valquiria Linck
Dora, Cristiana Lima
Batista, Matheus Monteiro
Horn, Ana Paula
Balestrin, Lucélia Albarello
Carrasco, Mariana Corrêa Falkembach
Fachel, Flávia Nathiely Silveira
Teixeira, Helder Ferreira
Back, Patrícia Inês
Araújo, Gabriela de Moraes Soares
Koester, Leticia Scherer
AuthorAffiliation 3 Programa de Pós-Graduação em Ciências da Saúde (PPGCS), Laboratório de Nanotecnologia, Faculdade de Medicina, Universidade Federal do Rio Grande (FURG), Rua Visconde de Paranaguá 102, Rio Grande 96203-900, Rio Grande do Sul, Brazil
2 Programa de Pós-Graduação em Ciências Fisiológicas (PPGCF), Laboratório de Histologia, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande (FURG), Av. Itália, km 8, s/n, Rio Grande 96203-900, Rio Grande do Sul, Brazil
1 Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil
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– name: 1 Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil
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Keywords nanoemulsion
Achyrocline satureioides
hydrogel
healing activity
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Snippet (Lam.) DC extract-loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the...
Achyrocline satureioides (Lam.) DC extract–loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte...
Achyrocline satureioides (Lam.) DC extract–loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte...
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SubjectTerms Achyrocline satureioides
Animals
Ethanol
Flavonoids
healing activity
Herbal medicine
hydrogel
Hydrogels
Injuries
nanoemulsion
Nanoemulsions
Skin
Triglycerides
Wound healing
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Title Effect of Hydrogel Containing Achyrocline satureioides (Asteraceae) Extract-Loaded Nanoemulsions on Wound Healing Activity
URI https://www.ncbi.nlm.nih.gov/pubmed/36559219
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https://pubmed.ncbi.nlm.nih.gov/PMC9788587
https://doaj.org/article/480a09a5a2484d23bef1e6e1bb6698fd
Volume 14
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