Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis

• Published in: Marine drugs Vol. 10; no. 3; pp. 639 - 654
• Main Authors: Xu, Min-Juan, Liu, Xiao-Jin, Zhao, Yi-Lei, Liu, Dong, Xu, Zhen-Hao, Lang, Xiao-Meng, Ao, Ping, Lin, Wen-Han, Yang, Song-Lin, Zhang, Zhi-Gang, Xu, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2012; MDPI
• Subjects: anti-contractile capacity; anti-fibrosis; benzopyran; Benzopyrans - isolation & purification; Benzopyrans - pharmacology; Biological effects; Carbonyl compounds; Cell Adhesion - drug effects; Cell Line; Cell Line, Tumor; Cell Proliferation - drug effects; Chromatography, High Pressure Liquid; Collagen - chemistry; fibroblast; Fibroblasts - drug effects; Fibrosis - drug therapy; Geologic Sediments - microbiology; Humans; Hydrolysis; Indicators and Reagents; Leukemia; Magnetic Resonance Spectroscopy; mangrove; Marine; Molecular Conformation; Streptomyces; Streptomyces - growth & development; Streptomyces - metabolism; Streptomyces xiamenensis; Trees - microbiology; Xiamenensis; anti-contractile capacity; anti-fibrosis; fibroblast; mangrove; benzopyran; Streptomyces xiamenensis

An anti-fibrotic compound produced by Streptomyces xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4¢R-methyl-3¢S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated f...