The ectodysplasin pathway: from diseases to adaptations

• Published in: Trends in genetics Vol. 30; no. 1; pp. 24 - 31
• Main Authors: Sadier, Alexa, Viriot, Laurent, Pantalacci, Sophie, Laudet, Vincent
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2014
• Subjects: adaptation; Adaptation, Physiological - genetics; anhidrotic/hypohidrotic ectodermal dysplasia; Animals; ectodermal appendages; Ectodermal Dysplasia 1, Anhidrotic - genetics; ectodysplasin; Ectodysplasins - genetics; Ectodysplasins - metabolism; Edar Receptor - genetics; Edar Receptor - metabolism; Edar-Associated Death Domain Protein - genetics; Edar-Associated Death Domain Protein - metabolism; Gene Expression Regulation; Humans; Medical Education; NF-kappa B - genetics; NF-kappa B - metabolism; Receptors, Tumor Necrosis Factor - genetics; Receptors, Tumor Necrosis Factor - metabolism; Signal Transduction; signaling pathways; Vertebrates - genetics; ectodermal appendages; adaptation; ectodysplasin; anhidrotic/hypohidrotic ectodermal dysplasia; signaling pathways

•The Ectodysplasin pathway controls ectodermal appendages in vertebrates.•The core of the pathway contains three main gene products: EDA, EDAR, and EDARADD.•Mutation of the pathway causes anhidrotic/hypohidrotic ectodermal dysplasia in humans.•The EDA pathway has been associated with specific adapta...