Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis
As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxyge...
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| Published in | Archives of pharmacal research Vol. 38; no. 8; pp. 1477 - 1487 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Seoul
Pharmaceutical Society of Korea
01.08.2015
대한약학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-6269 1976-3786 1976-3786 |
| DOI | 10.1007/s12272-014-0515-1 |
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| Abstract | As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) generation. Eisenia bicyclis exhibited promising inhibitory properties against AChE, BChE and total ROS with inhibition percentages (%) of 68.01 ± 1.37, 95.72 ± 3.80, and 73.20 ± 1.82 at concentrations of 25 µg/mL, respectively. Among the different solvent–soluble fractions obtained from the ethanolic extract, the ethyl acetate (EtOAc) fraction was found to cause the most potent scavenging, or inhibitory activities, against 2,2-diphenyl-1-picrylhydrazyl (DPPH), peroxynitrite (ONOO⁻) and total ROS with the respective IC₅₀ values of 2.48 ± 0.01, 8.70 ± 0.06, and 0.81 ± 0.03 µg/mL. Likewise, the EtOAc fraction also exhibited potent inhibitory activities against AChE and BChE with IC₅₀ values of 2.78 ± 0.07 and 3.48 ± 0.32 µg/mL, respectively. Silica gel column chromatography of the EtOAc fraction yielded a phlorotannin, 974-B, based on the comparison with reported ¹H- and ¹³C-NMR spectroscopic data. 974-B showed strong scavenging/or inhibitory potential against DPPH, ONOO⁻, total ROS, AChE, and BChE with the respective IC₅₀ values of 0.86 ± 0.02, 1.80 ± 0.01, 6.45 ± 0.04, 1.95 ± 0.01, and 3.26 ± 0.08 µM, respectively. These results indicate that the potential of E. bicyclis and its phlorotannin for use in the development of therapeutic or preventive agents of Alzheimer’s disease mainly through ChE inhibition and additional antioxidant capacities. |
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| AbstractList | As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) generation. Eisenia bicyclis exhibited promising inhibitory properties against AChE, BChE and total ROS with inhibition percentages (%) of 68.01 ± 1.37, 95.72 ± 3.80, and 73.20 ± 1.82 at concentrations of 25 lg/mL, respectively. Among the different solvent–soluble fractions obtained from the ethanolic extract,theethylacetate(EtOAc)fractionwasfoundtocause the most potent scavenging, or inhibitory activities, against 2,2-diphenyl-1-picrylhydrazyl (DPPH), peroxynitrite (ONOO-) and total ROS with the respective IC50 values of 2.48 ± 0.01, 8.70 ± 0.06, and 0.81 ± 0.03 lg/mL. Likewise, the EtOAc fraction also exhibited potent inhibitory activities against AChE and BChE with IC50 values of 2.78 ± 0.07 and 3.48 ± 0.32 lg/mL, respectively. Silica gel column chromatography of the EtOAc fraction yielded a phlorotannin, 974-B, based on the comparison with reported 1H- and 13C-NMR spectroscopic data. 974-B showed strong scavenging/or inhibitory potential against DPPH, ONOO-, total ROS, AChE, and BChE with the respective IC50 values of0.86 ± 0.02,1.80 ± 0.01,6.45 ± 0.04,1.95 ± 0.01,and 3.26 ± 0.08 lM, respectively. These results indicate thatthe potential of E. bicyclis and its phlorotannin for use in the development of therapeutic or preventive agents of Alzheimer’s disease mainly through ChE inhibition and additional antioxidant capacities. KCI Citation Count: 20 As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) generation. Eisenia bicyclis exhibited promising inhibitory properties against AChE, BChE and total ROS with inhibition percentages (%) of 68.01 ± 1.37, 95.72 ± 3.80, and 73.20 ± 1.82 at concentrations of 25 µg/mL, respectively. Among the different solvent-soluble fractions obtained from the ethanolic extract, the ethyl acetate (EtOAc) fraction was found to cause the most potent scavenging, or inhibitory activities, against 2,2-diphenyl-1-picrylhydrazyl (DPPH), peroxynitrite (ONOO(-)) and total ROS with the respective IC50 values of 2.48 ± 0.01, 8.70 ± 0.06, and 0.81 ± 0.03 µg/mL. Likewise, the EtOAc fraction also exhibited potent inhibitory activities against AChE and BChE with IC50 values of 2.78 ± 0.07 and 3.48 ± 0.32 µg/mL, respectively. Silica gel column chromatography of the EtOAc fraction yielded a phlorotannin, 974-B, based on the comparison with reported (1)H- and (13)C-NMR spectroscopic data. 974-B showed strong scavenging/or inhibitory potential against DPPH, ONOO(-), total ROS, AChE, and BChE with the respective IC50 values of 0.86 ± 0.02, 1.80 ± 0.01, 6.45 ± 0.04, 1.95 ± 0.01, and 3.26 ± 0.08 µM, respectively. These results indicate that the potential of E. bicyclis and its phlorotannin for use in the development of therapeutic or preventive agents of Alzheimer's disease mainly through ChE inhibition and additional antioxidant capacities. As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) generation. Eisenia bicyclis exhibited promising inhibitory properties against AChE, BChE and total ROS with inhibition percentages (%) of 68.01 ± 1.37, 95.72 ± 3.80, and 73.20 ± 1.82 at concentrations of 25 µg/mL, respectively. Among the different solvent–soluble fractions obtained from the ethanolic extract, the ethyl acetate (EtOAc) fraction was found to cause the most potent scavenging, or inhibitory activities, against 2,2-diphenyl-1-picrylhydrazyl (DPPH), peroxynitrite (ONOO⁻) and total ROS with the respective IC₅₀ values of 2.48 ± 0.01, 8.70 ± 0.06, and 0.81 ± 0.03 µg/mL. Likewise, the EtOAc fraction also exhibited potent inhibitory activities against AChE and BChE with IC₅₀ values of 2.78 ± 0.07 and 3.48 ± 0.32 µg/mL, respectively. Silica gel column chromatography of the EtOAc fraction yielded a phlorotannin, 974-B, based on the comparison with reported ¹H- and ¹³C-NMR spectroscopic data. 974-B showed strong scavenging/or inhibitory potential against DPPH, ONOO⁻, total ROS, AChE, and BChE with the respective IC₅₀ values of 0.86 ± 0.02, 1.80 ± 0.01, 6.45 ± 0.04, 1.95 ± 0.01, and 3.26 ± 0.08 µM, respectively. These results indicate that the potential of E. bicyclis and its phlorotannin for use in the development of therapeutic or preventive agents of Alzheimer’s disease mainly through ChE inhibition and additional antioxidant capacities. As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) generation. Eisenia bicyclis exhibited promising inhibitory properties against AChE, BChE and total ROS with inhibition percentages (%) of 68.01 ± 1.37, 95.72 ± 3.80, and 73.20 ± 1.82 at concentrations of 25 µg/mL, respectively. Among the different solvent-soluble fractions obtained from the ethanolic extract, the ethyl acetate (EtOAc) fraction was found to cause the most potent scavenging, or inhibitory activities, against 2,2-diphenyl-1-picrylhydrazyl (DPPH), peroxynitrite (ONOO(-)) and total ROS with the respective IC50 values of 2.48 ± 0.01, 8.70 ± 0.06, and 0.81 ± 0.03 µg/mL. Likewise, the EtOAc fraction also exhibited potent inhibitory activities against AChE and BChE with IC50 values of 2.78 ± 0.07 and 3.48 ± 0.32 µg/mL, respectively. Silica gel column chromatography of the EtOAc fraction yielded a phlorotannin, 974-B, based on the comparison with reported (1)H- and (13)C-NMR spectroscopic data. 974-B showed strong scavenging/or inhibitory potential against DPPH, ONOO(-), total ROS, AChE, and BChE with the respective IC50 values of 0.86 ± 0.02, 1.80 ± 0.01, 6.45 ± 0.04, 1.95 ± 0.01, and 3.26 ± 0.08 µM, respectively. These results indicate that the potential of E. bicyclis and its phlorotannin for use in the development of therapeutic or preventive agents of Alzheimer's disease mainly through ChE inhibition and additional antioxidant capacities.As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) generation. Eisenia bicyclis exhibited promising inhibitory properties against AChE, BChE and total ROS with inhibition percentages (%) of 68.01 ± 1.37, 95.72 ± 3.80, and 73.20 ± 1.82 at concentrations of 25 µg/mL, respectively. Among the different solvent-soluble fractions obtained from the ethanolic extract, the ethyl acetate (EtOAc) fraction was found to cause the most potent scavenging, or inhibitory activities, against 2,2-diphenyl-1-picrylhydrazyl (DPPH), peroxynitrite (ONOO(-)) and total ROS with the respective IC50 values of 2.48 ± 0.01, 8.70 ± 0.06, and 0.81 ± 0.03 µg/mL. Likewise, the EtOAc fraction also exhibited potent inhibitory activities against AChE and BChE with IC50 values of 2.78 ± 0.07 and 3.48 ± 0.32 µg/mL, respectively. Silica gel column chromatography of the EtOAc fraction yielded a phlorotannin, 974-B, based on the comparison with reported (1)H- and (13)C-NMR spectroscopic data. 974-B showed strong scavenging/or inhibitory potential against DPPH, ONOO(-), total ROS, AChE, and BChE with the respective IC50 values of 0.86 ± 0.02, 1.80 ± 0.01, 6.45 ± 0.04, 1.95 ± 0.01, and 3.26 ± 0.08 µM, respectively. These results indicate that the potential of E. bicyclis and its phlorotannin for use in the development of therapeutic or preventive agents of Alzheimer's disease mainly through ChE inhibition and additional antioxidant capacities. As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) generation. Eisenia bicyclis exhibited promising inhibitory properties against AChE, BChE and total ROS with inhibition percentages (%) of 68.01 ± 1.37, 95.72 ± 3.80, and 73.20 ± 1.82 at concentrations of 25 µg/mL, respectively. Among the different solvent–soluble fractions obtained from the ethanolic extract, the ethyl acetate (EtOAc) fraction was found to cause the most potent scavenging, or inhibitory activities, against 2,2-diphenyl-1-picrylhydrazyl (DPPH), peroxynitrite (ONOO⁻) and total ROS with the respective IC₅₀ values of 2.48 ± 0.01, 8.70 ± 0.06, and 0.81 ± 0.03 µg/mL. Likewise, the EtOAc fraction also exhibited potent inhibitory activities against AChE and BChE with IC₅₀ values of 2.78 ± 0.07 and 3.48 ± 0.32 µg/mL, respectively. Silica gel column chromatography of the EtOAc fraction yielded a phlorotannin, 974-B, based on the comparison with reported ¹H- and ¹³C-NMR spectroscopic data. 974-B showed strong scavenging/or inhibitory potential against DPPH, ONOO⁻, total ROS, AChE, and BChE with the respective IC₅₀ values of 0.86 ± 0.02, 1.80 ± 0.01, 6.45 ± 0.04, 1.95 ± 0.01, and 3.26 ± 0.08 µM, respectively. These results indicate that the potential of E. bicyclis and its phlorotannin for use in the development of therapeutic or preventive agents of Alzheimer’s disease mainly through ChE inhibition and additional antioxidant capacities. As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and total reactive oxygen species (ROS) generation. Eisenia bicyclis exhibited promising inhibitory properties against AChE, BChE and total ROS with inhibition percentages (%) of 68.01 ± 1.37, 95.72 ± 3.80, and 73.20 ± 1.82 at concentrations of 25 µg/mL, respectively. Among the different solvent–soluble fractions obtained from the ethanolic extract, the ethyl acetate (EtOAc) fraction was found to cause the most potent scavenging, or inhibitory activities, against 2,2-diphenyl-1-picrylhydrazyl (DPPH), peroxynitrite (ONOO − ) and total ROS with the respective IC 50 values of 2.48 ± 0.01, 8.70 ± 0.06, and 0.81 ± 0.03 µg/mL. Likewise, the EtOAc fraction also exhibited potent inhibitory activities against AChE and BChE with IC 50 values of 2.78 ± 0.07 and 3.48 ± 0.32 µg/mL, respectively. Silica gel column chromatography of the EtOAc fraction yielded a phlorotannin, 974-B, based on the comparison with reported 1 H- and 13 C-NMR spectroscopic data. 974-B showed strong scavenging/or inhibitory potential against DPPH, ONOO − , total ROS, AChE, and BChE with the respective IC 50 values of 0.86 ± 0.02, 1.80 ± 0.01, 6.45 ± 0.04, 1.95 ± 0.01, and 3.26 ± 0.08 µM, respectively. These results indicate that the potential of E. bicyclis and its phlorotannin for use in the development of therapeutic or preventive agents of Alzheimer’s disease mainly through ChE inhibition and additional antioxidant capacities. |
| Author | Kim, Hyeung Rak Jung, Hee Jin Jung, Hyun Ah Haulader, Shourav Karki, Subash Choi, Jae Sue |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25370610$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002017955$$DAccess content in National Research Foundation of Korea (NRF) |
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| Cites_doi | 10.1016/j.jnutbio.2013.05.001 10.1021/jf802732n 10.5507/bp.2009.032 10.1016/j.biortech.2006.07.034 10.1073/pnas.88.23.10540 10.1097/00001756-199612200-00020 10.1016/0891-5849(94)90138-4 10.2174/1381612043383331 10.1016/0006-2952(61)90145-9 10.1016/j.cell.2005.02.008 10.1016/j.ejphar.2009.05.017 10.1021/jf071569n 10.1016/S0165-0173(99)00014-4 10.1016/S1471-4914(01)02173-6 10.1097/00002093-200304000-00002 10.1016/S0891-5849(96)00629-6 10.1007/BF02969360 10.1016/0197-0186(90)90025-O 10.1351/pac200173030555 10.1016/j.etap.2011.09.004 10.1002/ptr.2674 10.1016/j.freeradbiomed.2007.05.037 10.1016/j.bmc.2008.07.078 10.1016/S0925-4439(00)00040-5 10.1016/S0304-3940(99)00751-X 10.1016/j.bmc.2009.01.031 10.3390/md11010165 10.1016/j.fct.2013.05.061 10.1155/2014/497802 10.1185/03007990152673800 10.1016/j.neulet.2009.11.001 10.1155/2011/467180 10.1016/j.biocel.2006.07.001 10.1016/j.biortech.2004.07.013 10.1016/j.phytochem.2004.08.052 10.1016/j.bbagen.2014.05.005 10.3390/md9050803 10.2174/157015909787602823 10.1016/j.mehy.2007.03.032 10.1002/jcb.20668 10.5657/fas.2009.12.3.194 10.5657/FAS.2013.0001 10.1016/j.algal.2012.10.002 10.1078/094471103321648647 10.1038/1811199a0 10.1007/s12272-012-1116-5 10.1002/ptr.2090 10.1007/s12257-009-0052-9 10.1016/j.bmcl.2010.04.093 10.1016/j.fct.2009.04.013 10.1248/bpb.29.1212 10.1016/j.jep.2003.11.016 10.1016/j.jocn.2003.12.007 10.1111/j.1750-3841.2010.01915.x 10.1126/science.1132813 10.1111/j.1444-2906.2007.01511.x |
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| PublicationTitle | Archives of pharmacal research |
| PublicationTitleAbbrev | Arch. Pharm. Res |
| PublicationTitleAlternate | Arch Pharm Res |
| PublicationYear | 2015 |
| Publisher | Pharmaceutical Society of Korea 대한약학회 |
| Publisher_xml | – name: Pharmaceutical Society of Korea – name: 대한약학회 |
| References | Lebel, Bondy (CR30) 1990; 17 Markesbery (CR37) 1997; 23 Yotsu-Yamashita, Kondo, Segawa, Lin, Toyohara, Ito, Konoki, Cho, Uchida (CR55) 2013; 11 Cecchi, Latorraca, Sorbi, Iantomasi, Favilli, Vincenzini, Liquri (CR10) 1999; 275 Houghton, Agbedahunsi, Adegbulugbe (CR19) 2004; 65 Butterfield, Reed, Newman, Sultana (CR8) 2007; 43 Heo, Hwang, Choi, Han, Kim, Jeon (CR18) 2009; 615 Torreilles, Salman-Tabcheh, Guérin, Torreilles (CR50) 1999; 30 Jha, Rizvi (CR21) 2009; 153 Kong, Kim, Yoon, Kim (CR27) 2009; 47 Roberson, Mucke (CR44) 2006; 314 Fallarero, Loikkanen, Männistö, Castañeda, Vidal (CR15) 2003; 10 Pangestuti, Kim (CR41) 2011; 9 Cardona, Andrés-Lacueva, Tulipani, Tinahones, Queipo-Ortuño (CR9) 2013; 24 Liu, Qiu, Wang, Wang, Su, Gao, Gu, Xu, Huang, Gu, Huang, Li (CR34) 2014; 1840 Greig, Utsuki, Yu, Zhu, Holloway, Perry, Lee, Ingram, Lahiri (CR16) 2001; 17 Maeda, Hosokawa, Sashima, Miyashita (CR36) 2007; 55 Uttara, Singh, Zamboni, Mahajan (CR51) 2009; 7 Khan, Kong, Kim, Kim (CR25) 2010; 15 Ahn, Moon, Kim, Jung, Choi (CR1) 2012; 35 Tanzi, Bertram (CR48) 2005; 120 Yoon, Lee, Shim, Lim, Lee, Cho, Xie (CR54) 2013; 16 Wimo, Winblad, Aguero-Torres, Von Strauss (CR53) 2003; 17 Choi, Ryu, Park, Kim, Shin, Roh, Shin, Lee (CR12) 2007; 21 Cheng, Ren, Tang (CR11) 1996; 8 Kooy, Royall, Ischiropoulos, Beckman (CR28) 1994; 16 Orhan, Sener, Choudhary, Khalid (CR40) 2004; 91 Jung, Oh, Choi (CR23) 2010; 20 Lim, Jin, Sung, Lee, Choi, Ha, Han (CR33) 2006; 29 Valko, Leibfritz, Moncol, Cronin, Mazur, Telser (CR52) 2007; 39 Thomas, Kim (CR49) 2011; 32 Butterfield, Drake, Pocernich, Castegna (CR7) 2001; 7 Ermakova, Men’shova, Vishchuk, Kim, Um, Isakov, Zvyagintseva (CR14) 2013; 2 Jeong, Yoon, Kim (CR20) 2009; 12 CR56 Rao, Sridhar, Das (CR43) 2007; 69 Smith, Rottkamp, Nunomura, Raina, Perry (CR46) 2000; 1502 Li, Lee, Le, Kim, Kim (CR31) 2008; 56 Heo, Park, Lee, Jeon (CR17) 2005; 96 Blois (CR6) 1958; 181 Airanthi, Hosokawa, Miyashita (CR2) 2011; 76 Myung, Shin, Bao, Yeo, Lee, Kang (CR39) 2005; 28 Suganthy, Karutha, Pandima (CR47) 2010; 468 Li, Qian, Ryu, Lee, Kim, Kim (CR32) 2009; 17 Lahiri, Rogers, Sambamurti, Greig (CR29) 2004; 10 Jung, Jin, Ahn, Lee, Choi (CR22) 2013; 59 Parihar, Hemnani (CR42) 2004; 11 Atta-ur-Rahman, Choudhary (CR5) 2001; 73 Luque-Contreras, Carvajal, Toral-Rios, Franco-Bocanegra, Campos-Peña (CR35) 2014; 2014 Athukorala, Lee, Kim, Jeon (CR4) 2007; 98 Kang, Lee, Chae, Zhang, Jung, Ham, Baik, Lee, Hyun (CR24) 2006; 97 Smith, Carney, Starke-Reed, Oliver, Stadtman, Floyd, Markesbery (CR45) 1991; 88 Kim, Rajapakse, Kim (CR26) 2009; 23 Artan, Li, Karadeniz, Lee, Kim, Kim (CR3) 2008; 16 Melo, Monteiro, Lima, Oliveira, Cerqueira, El-Bacha (CR38) 2011; 2011 Ellman, Courtney, Andres, Featherstone (CR13) 1961; 7 Y Athukorala (515_CR4) 2007; 98 NV Thomas (515_CR49) 2011; 32 S Ermakova (515_CR14) 2013; 2 SJ Heo (515_CR18) 2009; 615 DA Butterfield (515_CR7) 2001; 7 I Orhan (515_CR40) 2004; 91 BW Choi (515_CR12) 2007; 21 ES Jeong (515_CR20) 2009; 12 Y Li (515_CR31) 2008; 56 AA Rao (515_CR43) 2007; 69 NW Kooy (515_CR28) 1994; 16 BR Ahn (515_CR1) 2012; 35 WR Markesbery (515_CR37) 1997; 23 MA Smith (515_CR46) 2000; 1502 H Maeda (515_CR36) 2007; 55 DH Cheng (515_CR11) 1996; 8 R Pangestuti (515_CR41) 2011; 9 HA Jung (515_CR23) 2010; 20 F Torreilles (515_CR50) 1999; 30 MM Kim (515_CR26) 2009; 23 CS Lim (515_CR33) 2006; 29 M Valko (515_CR52) 2007; 39 MS Blois (515_CR6) 1958; 181 A Wimo (515_CR53) 2003; 17 CP Lebel (515_CR30) 1990; 17 Y Li (515_CR32) 2009; 17 SJ Heo (515_CR17) 2005; 96 PJ Houghton (515_CR19) 2004; 65 515_CR56 MK Airanthi (515_CR2) 2011; 76 KA Kang (515_CR24) 2006; 97 M Uttara (515_CR51) 2009; 7 A Fallarero (515_CR15) 2003; 10 D Luque-Contreras (515_CR35) 2014; 2014 J Liu (515_CR34) 2014; 1840 N Suganthy (515_CR47) 2010; 468 ED Roberson (515_CR44) 2006; 314 HA Jung (515_CR22) 2013; 59 CS Myung (515_CR39) 2005; 28 NY Yoon (515_CR54) 2013; 16 R Jha (515_CR21) 2009; 153 CS Kong (515_CR27) 2009; 47 NH Greig (515_CR16) 2001; 17 GL Ellman (515_CR13) 1961; 7 M Yotsu-Yamashita (515_CR55) 2013; 11 A Melo (515_CR38) 2011; 2011 CD Smith (515_CR45) 1991; 88 DK Lahiri (515_CR29) 2004; 10 RE Tanzi (515_CR48) 2005; 120 M Artan (515_CR3) 2008; 16 SB Khan (515_CR25) 2010; 15 F Cardona (515_CR9) 2013; 24 MS Parihar (515_CR42) 2004; 11 Atta-ur-Rahman (515_CR5) 2001; 73 C Cecchi (515_CR10) 1999; 275 DA Butterfield (515_CR8) 2007; 43 |
| References_xml | – volume: 24 start-page: 1415 year: 2013 end-page: 1422 ident: CR9 article-title: Benefits of polyphenols on gut microbiota and implications in human health publication-title: The Journal of Nutritional Biochemistry doi: 10.1016/j.jnutbio.2013.05.001 – volume: 56 start-page: 12073 year: 2008 end-page: 12080 ident: CR31 article-title: Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc epsilonRI publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf802732n – volume: 153 start-page: 195 year: 2009 end-page: 198 ident: CR21 article-title: Age-dependent decline in erythrocyte acetylcholinesterase activity: Correlation with oxidative stress publication-title: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia doi: 10.5507/bp.2009.032 – volume: 98 start-page: 1711 year: 2007 end-page: 1716 ident: CR4 article-title: Anticoagulant activity of marine green and brown algae collected from Jeju Island in Korea publication-title: Bioresource Technology doi: 10.1016/j.biortech.2006.07.034 – volume: 88 start-page: 10540 year: 1991 end-page: 10543 ident: CR45 article-title: Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer’s disease publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.88.23.10540 – volume: 8 start-page: 97 year: 1996 end-page: 101 ident: CR11 article-title: Huperzine A, a novel promising acetylcholinesterase inhibitor publication-title: NeuroReport doi: 10.1097/00001756-199612200-00020 – volume: 16 start-page: 149 year: 1994 end-page: 156 ident: CR28 article-title: Peroxynitrite-mediated oxidation of dihydrorhodamine 123 publication-title: Free Radical Biology and Medicine doi: 10.1016/0891-5849(94)90138-4 – volume: 10 start-page: 3111 year: 2004 end-page: 3119 ident: CR29 article-title: Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents publication-title: Current Pharmaceutical Design doi: 10.2174/1381612043383331 – volume: 7 start-page: 88 year: 1961 end-page: 95 ident: CR13 article-title: A new and rapid colorimetric determination of acetylcholinesterase activity publication-title: Biochemistry and Pharmacology doi: 10.1016/0006-2952(61)90145-9 – volume: 120 start-page: 545 year: 2005 end-page: 555 ident: CR48 article-title: Twenty years of the Alzheimer’s disease amyloid hypothesis: A genetic perspective publication-title: Cells doi: 10.1016/j.cell.2005.02.008 – volume: 615 start-page: 252 year: 2009 end-page: 256 ident: CR18 article-title: Diphlorethohydroxycarmalol isolated from , a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice publication-title: European Journal of Pharmacology doi: 10.1016/j.ejphar.2009.05.017 – volume: 55 start-page: 7701 year: 2007 end-page: 7706 ident: CR36 article-title: Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay Mice publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf071569n – volume: 30 start-page: 153 year: 1999 end-page: 163 ident: CR50 article-title: Neurodegenerative disorders: The role of peroxynitrite publication-title: Brain Research Reviews doi: 10.1016/S0165-0173(99)00014-4 – volume: 7 start-page: 548 year: 2001 end-page: 554 ident: CR7 article-title: Evidence of oxidative damage in Alzheimer’s diseases brain: Central role for amyloid β-peptide publication-title: Trends in Molecular Medicine doi: 10.1016/S1471-4914(01)02173-6 – volume: 17 start-page: 63 year: 2003 end-page: 67 ident: CR53 article-title: The magnitude of dementia occurrence in the world publication-title: Alzheimer Disease and Associated Disorders doi: 10.1097/00002093-200304000-00002 – volume: 23 start-page: 134 year: 1997 end-page: 147 ident: CR37 article-title: Oxidative stress hypothesis in Alzheimer’s diseases publication-title: Free Radical Biology and Medicine doi: 10.1016/S0891-5849(96)00629-6 – volume: 28 start-page: 691 year: 2005 end-page: 698 ident: CR39 article-title: Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: Possible involvement of the inhibition of acetylcholinesterase publication-title: Archives of Pharmacal Research doi: 10.1007/BF02969360 – volume: 17 start-page: 435 year: 1990 end-page: 440 ident: CR30 article-title: Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes publication-title: Neurochemistry International doi: 10.1016/0197-0186(90)90025-O – volume: 73 start-page: 555 year: 2001 end-page: 560 ident: CR5 article-title: Bioactive natural products as a potential source of new pharmacophores. A theory of memory publication-title: Pure and Applied Chemistry doi: 10.1351/pac200173030555 – volume: 32 start-page: 325 year: 2011 end-page: 335 ident: CR49 article-title: Potential pharmacological applications of polyphenolic derivatives from marine brown algae publication-title: Environmental Toxicology and Pharmacology doi: 10.1016/j.etap.2011.09.004 – volume: 23 start-page: 628 year: 2009 end-page: 634 ident: CR26 article-title: Anti-inflammatory effect of ethanolic extract via inhibition of NF-κB transcription factor in RAW 264.7 cells publication-title: Phytotherapy Research doi: 10.1002/ptr.2674 – volume: 43 start-page: 658 year: 2007 end-page: 677 ident: CR8 article-title: Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer’s diseases and mild cognitive impairment publication-title: Free Radical Biology and Medicine doi: 10.1016/j.freeradbiomed.2007.05.037 – volume: 16 start-page: 7921 year: 2008 end-page: 7926 ident: CR3 article-title: Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from publication-title: Bioorganic and Medicinal Chemistry doi: 10.1016/j.bmc.2008.07.078 – volume: 1502 start-page: 139 year: 2000 end-page: 144 ident: CR46 article-title: Oxidative stress in Alzheimer’s disease publication-title: Biochimica et Biophysica Acta doi: 10.1016/S0925-4439(00)00040-5 – volume: 275 start-page: 152 year: 1999 end-page: 154 ident: CR10 article-title: Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer’s disease publication-title: Neuroscience Letters doi: 10.1016/S0304-3940(99)00751-X – volume: 17 start-page: 1963 year: 2009 end-page: 1973 ident: CR32 article-title: Chemical components and its antioxidant properties in vitro: an edible marine brown alga, publication-title: Bioorganic and Medicinal Chemistry doi: 10.1016/j.bmc.2009.01.031 – volume: 11 start-page: 165 year: 2013 end-page: 183 ident: CR55 article-title: Isolation and structural determination of two novel phlorotannins from the brown alga Okamura, and their radical scavenging activities publication-title: Marine Drugs doi: 10.3390/md11010165 – volume: 59 start-page: 199 year: 2013 end-page: 206 ident: CR22 article-title: Anti-inflammatory activity of edible brown alga and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2013.05.061 – volume: 2014 start-page: 1 year: 2014 end-page: 11 ident: CR35 article-title: Oxidative stress and metabolic syndrome: Cause or consequence of Alzheimer’s diseases? publication-title: Oxidative Medicine and Cellular Longevity doi: 10.1155/2014/497802 – volume: 17 start-page: 159 year: 2001 end-page: 165 ident: CR16 article-title: A new therapeutic target in Alzheimer’s disease treatment: Attention to butyrylcholinesterase publication-title: Current Medical Research and Opinion doi: 10.1185/03007990152673800 – volume: 468 start-page: 216 year: 2010 end-page: 219 ident: CR47 article-title: Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar marine biosphere reserve): Cholinesterase inhibitory effect of and publication-title: Neuroscience Letters doi: 10.1016/j.neulet.2009.11.001 – volume: 2011 start-page: 1 year: 2011 end-page: 14 ident: CR38 article-title: Oxidative stress in neurodegenerative diseases: Mechanisms and therapeutic perspectives publication-title: Oxidative Medicine and Cellular Longevity doi: 10.1155/2011/467180 – volume: 39 start-page: 44 year: 2007 end-page: 84 ident: CR52 article-title: Free radicals and antioxidants in normal physiological functions and human disease publication-title: International Journal of Biochemistry & Cell Biology doi: 10.1016/j.biocel.2006.07.001 – volume: 96 start-page: 1613 year: 2005 end-page: 1623 ident: CR17 article-title: Antioxidant activities of enzymatic extracts from brown seaweeds publication-title: Bioresource Technology doi: 10.1016/j.biortech.2004.07.013 – volume: 65 start-page: 2893 year: 2004 end-page: 2896 ident: CR19 article-title: Choline esterase inhibitory properties of alkaloids from two Nigerian Crinum species publication-title: Phytochemistry doi: 10.1016/j.phytochem.2004.08.052 – volume: 1840 start-page: 2886 year: 2014 end-page: 2903 ident: CR34 article-title: Synthesis and characterization of 1H-phenanthro[9,10- ] imidazole derivatives as multifunctional agents for treatment of Alzheimer’s diseases publication-title: Biochimica et Biophysica Acta doi: 10.1016/j.bbagen.2014.05.005 – volume: 9 start-page: 803 year: 2011 end-page: 818 ident: CR41 article-title: Neuroprotective effects of marine algae publication-title: Marine Drugs doi: 10.3390/md9050803 – volume: 7 start-page: 65 year: 2009 end-page: 74 ident: CR51 article-title: Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options publication-title: Current Neuropharmacology doi: 10.2174/157015909787602823 – volume: 69 start-page: 1272 year: 2007 end-page: 1276 ident: CR43 article-title: Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer’s diseases publication-title: Medical Hypotheses doi: 10.1016/j.mehy.2007.03.032 – volume: 97 start-page: 609 year: 2006 end-page: 620 ident: CR24 article-title: Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation publication-title: Journal of Cellular Biochemistry doi: 10.1002/jcb.20668 – ident: CR56 – volume: 12 start-page: 194 year: 2009 end-page: 202 ident: CR20 article-title: Contrasting correlation in the inhibition response of ADP-induced platelet aggregation and the anti-coagulant activities of algal fucoidans derived from and - sporophylls (Mekabu) publication-title: Fisheries Aquatic Sciences doi: 10.5657/fas.2009.12.3.194 – volume: 16 start-page: 1 year: 2013 end-page: 5 ident: CR54 article-title: Quinone reductase induction activity of phlorotannins derived from in Hepa1c1c7 cells publication-title: Fisheries Aquatic Sciences doi: 10.5657/FAS.2013.0001 – volume: 2 start-page: 51 year: 2013 end-page: 58 ident: CR14 article-title: Water-soluble polysaccharides from the brown alga : Structural characteristics and antitumor activity publication-title: Algal Research doi: 10.1016/j.algal.2012.10.002 – volume: 10 start-page: 39 year: 2003 end-page: 47 ident: CR15 article-title: Effects of aqueous extracts of (Ellis) Lamouroux and (S.G.Gmelim) Howe on hydrogen peroxide and methyl mercury-induced oxidative stress in GT1–7 mouse hypothalamic immortalized cells publication-title: Phytomedicine doi: 10.1078/094471103321648647 – volume: 181 start-page: 1199 year: 1958 end-page: 1200 ident: CR6 article-title: Antioxidant determination by the use of a stable free radical publication-title: Nature doi: 10.1038/1811199a0 – volume: 35 start-page: 1989 year: 2012 end-page: 1998 ident: CR1 article-title: Neuroprotective effect of edible brown alga on amyloid beta peptide-induced toxicity in PC12 cells publication-title: Archives of Pharmacal Research doi: 10.1007/s12272-012-1116-5 – volume: 21 start-page: 423 year: 2007 end-page: 426 ident: CR12 article-title: Anticholinesterase activity of plastoquinones from : Lead compounds for Alzheimer’s diseases therapy publication-title: Phytotherapy Research doi: 10.1002/ptr.2090 – volume: 15 start-page: 191 year: 2010 end-page: 198 ident: CR25 article-title: Protective effect of on ROS induced oxidative damage and MMP expressions in HT1080 cells publication-title: Biotechnology Bioprocess Engineering doi: 10.1007/s12257-009-0052-9 – volume: 20 start-page: 3211 year: 2010 end-page: 3215 ident: CR23 article-title: Molecular docking studies of phlorotannins from with BACE1 inhibitory activity publication-title: Bioorganic & Medicinal Chemistry Letters doi: 10.1016/j.bmcl.2010.04.093 – volume: 47 start-page: 1653 year: 2009 end-page: 1658 ident: CR27 article-title: Induction of apoptosis by phloroglucinol derivative from in MCF-7 human breast cancer cells publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2009.04.013 – volume: 29 start-page: 1212 year: 2006 end-page: 1216 ident: CR33 article-title: Antioxidant and anti-inflammatory activities of the methanolic extract of in hippocampal and microglial cells publication-title: Biological and Pharmaceutical Bulletin doi: 10.1248/bpb.29.1212 – volume: 91 start-page: 57 year: 2004 end-page: 60 ident: CR40 article-title: Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2003.11.016 – volume: 11 start-page: 456 year: 2004 end-page: 467 ident: CR42 article-title: Alzheimer’s diseases pathogenesis and therapeutic interventions publication-title: Journal of Clinical Neuroscience doi: 10.1016/j.jocn.2003.12.007 – volume: 76 start-page: 104 year: 2011 end-page: 111 ident: CR2 article-title: Comparative antioxidant activity of edible Japanese brown seaweeds publication-title: Journal of Food Science doi: 10.1111/j.1750-3841.2010.01915.x – volume: 314 start-page: 781 year: 2006 end-page: 784 ident: CR44 article-title: 100 years and counting: Prospects for defeating Alzheimer’s disease publication-title: Science doi: 10.1126/science.1132813 – volume: 11 start-page: 165 year: 2013 ident: 515_CR55 publication-title: Marine Drugs doi: 10.3390/md11010165 – volume: 2014 start-page: 1 year: 2014 ident: 515_CR35 publication-title: Oxidative Medicine and Cellular Longevity doi: 10.1155/2014/497802 – volume: 7 start-page: 548 year: 2001 ident: 515_CR7 publication-title: Trends in Molecular Medicine doi: 10.1016/S1471-4914(01)02173-6 – volume: 9 start-page: 803 year: 2011 ident: 515_CR41 publication-title: Marine Drugs doi: 10.3390/md9050803 – volume: 10 start-page: 39 year: 2003 ident: 515_CR15 publication-title: Phytomedicine doi: 10.1078/094471103321648647 – ident: 515_CR56 doi: 10.1111/j.1444-2906.2007.01511.x – volume: 96 start-page: 1613 year: 2005 ident: 515_CR17 publication-title: Bioresource Technology doi: 10.1016/j.biortech.2004.07.013 – volume: 15 start-page: 191 year: 2010 ident: 515_CR25 publication-title: Biotechnology Bioprocess Engineering doi: 10.1007/s12257-009-0052-9 – volume: 39 start-page: 44 year: 2007 ident: 515_CR52 publication-title: International Journal of Biochemistry & Cell Biology doi: 10.1016/j.biocel.2006.07.001 – volume: 23 start-page: 134 year: 1997 ident: 515_CR37 publication-title: Free Radical Biology and Medicine doi: 10.1016/S0891-5849(96)00629-6 – volume: 468 start-page: 216 year: 2010 ident: 515_CR47 publication-title: Neuroscience Letters doi: 10.1016/j.neulet.2009.11.001 – volume: 69 start-page: 1272 year: 2007 ident: 515_CR43 publication-title: Medical Hypotheses doi: 10.1016/j.mehy.2007.03.032 – volume: 55 start-page: 7701 year: 2007 ident: 515_CR36 publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf071569n – volume: 32 start-page: 325 year: 2011 ident: 515_CR49 publication-title: Environmental Toxicology and Pharmacology doi: 10.1016/j.etap.2011.09.004 – volume: 17 start-page: 159 year: 2001 ident: 515_CR16 publication-title: Current Medical Research and Opinion doi: 10.1185/03007990152673800 – volume: 23 start-page: 628 year: 2009 ident: 515_CR26 publication-title: Phytotherapy Research doi: 10.1002/ptr.2674 – volume: 7 start-page: 65 year: 2009 ident: 515_CR51 publication-title: Current Neuropharmacology doi: 10.2174/157015909787602823 – volume: 28 start-page: 691 year: 2005 ident: 515_CR39 publication-title: Archives of Pharmacal Research doi: 10.1007/BF02969360 – volume: 8 start-page: 97 year: 1996 ident: 515_CR11 publication-title: NeuroReport doi: 10.1097/00001756-199612200-00020 – volume: 56 start-page: 12073 year: 2008 ident: 515_CR31 publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf802732n – volume: 17 start-page: 435 year: 1990 ident: 515_CR30 publication-title: Neurochemistry International doi: 10.1016/0197-0186(90)90025-O – volume: 35 start-page: 1989 year: 2012 ident: 515_CR1 publication-title: Archives of Pharmacal Research doi: 10.1007/s12272-012-1116-5 – volume: 615 start-page: 252 year: 2009 ident: 515_CR18 publication-title: European Journal of Pharmacology doi: 10.1016/j.ejphar.2009.05.017 – volume: 1840 start-page: 2886 year: 2014 ident: 515_CR34 publication-title: Biochimica et Biophysica Acta doi: 10.1016/j.bbagen.2014.05.005 – volume: 10 start-page: 3111 year: 2004 ident: 515_CR29 publication-title: Current Pharmaceutical Design doi: 10.2174/1381612043383331 – volume: 65 start-page: 2893 year: 2004 ident: 515_CR19 publication-title: Phytochemistry doi: 10.1016/j.phytochem.2004.08.052 – volume: 47 start-page: 1653 year: 2009 ident: 515_CR27 publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2009.04.013 – volume: 17 start-page: 63 year: 2003 ident: 515_CR53 publication-title: Alzheimer Disease and Associated Disorders doi: 10.1097/00002093-200304000-00002 – volume: 16 start-page: 1 year: 2013 ident: 515_CR54 publication-title: Fisheries Aquatic Sciences doi: 10.5657/FAS.2013.0001 – volume: 1502 start-page: 139 year: 2000 ident: 515_CR46 publication-title: Biochimica et Biophysica Acta doi: 10.1016/S0925-4439(00)00040-5 – volume: 73 start-page: 555 year: 2001 ident: 515_CR5 publication-title: Pure and Applied Chemistry doi: 10.1351/pac200173030555 – volume: 29 start-page: 1212 year: 2006 ident: 515_CR33 publication-title: Biological and Pharmaceutical Bulletin doi: 10.1248/bpb.29.1212 – volume: 16 start-page: 149 year: 1994 ident: 515_CR28 publication-title: Free Radical Biology and Medicine doi: 10.1016/0891-5849(94)90138-4 – volume: 76 start-page: 104 year: 2011 ident: 515_CR2 publication-title: Journal of Food Science doi: 10.1111/j.1750-3841.2010.01915.x – volume: 30 start-page: 153 year: 1999 ident: 515_CR50 publication-title: Brain Research Reviews doi: 10.1016/S0165-0173(99)00014-4 – volume: 314 start-page: 781 year: 2006 ident: 515_CR44 publication-title: Science doi: 10.1126/science.1132813 – volume: 7 start-page: 88 year: 1961 ident: 515_CR13 publication-title: Biochemistry and Pharmacology doi: 10.1016/0006-2952(61)90145-9 – volume: 181 start-page: 1199 year: 1958 ident: 515_CR6 publication-title: Nature doi: 10.1038/1811199a0 – volume: 88 start-page: 10540 year: 1991 ident: 515_CR45 publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.88.23.10540 – volume: 2 start-page: 51 year: 2013 ident: 515_CR14 publication-title: Algal Research doi: 10.1016/j.algal.2012.10.002 – volume: 17 start-page: 1963 year: 2009 ident: 515_CR32 publication-title: Bioorganic and Medicinal Chemistry doi: 10.1016/j.bmc.2009.01.031 – volume: 12 start-page: 194 year: 2009 ident: 515_CR20 publication-title: Fisheries Aquatic Sciences doi: 10.5657/fas.2009.12.3.194 – volume: 24 start-page: 1415 year: 2013 ident: 515_CR9 publication-title: The Journal of Nutritional Biochemistry doi: 10.1016/j.jnutbio.2013.05.001 – volume: 11 start-page: 456 year: 2004 ident: 515_CR42 publication-title: Journal of Clinical Neuroscience doi: 10.1016/j.jocn.2003.12.007 – volume: 275 start-page: 152 year: 1999 ident: 515_CR10 publication-title: Neuroscience Letters doi: 10.1016/S0304-3940(99)00751-X – volume: 153 start-page: 195 year: 2009 ident: 515_CR21 publication-title: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia doi: 10.5507/bp.2009.032 – volume: 16 start-page: 7921 year: 2008 ident: 515_CR3 publication-title: Bioorganic and Medicinal Chemistry doi: 10.1016/j.bmc.2008.07.078 – volume: 91 start-page: 57 year: 2004 ident: 515_CR40 publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2003.11.016 – volume: 2011 start-page: 1 year: 2011 ident: 515_CR38 publication-title: Oxidative Medicine and Cellular Longevity doi: 10.1155/2011/467180 – volume: 20 start-page: 3211 year: 2010 ident: 515_CR23 publication-title: Bioorganic & Medicinal Chemistry Letters doi: 10.1016/j.bmcl.2010.04.093 – volume: 21 start-page: 423 year: 2007 ident: 515_CR12 publication-title: Phytotherapy Research doi: 10.1002/ptr.2090 – volume: 59 start-page: 199 year: 2013 ident: 515_CR22 publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2013.05.061 – volume: 97 start-page: 609 year: 2006 ident: 515_CR24 publication-title: Journal of Cellular Biochemistry doi: 10.1002/jcb.20668 – volume: 120 start-page: 545 year: 2005 ident: 515_CR48 publication-title: Cells doi: 10.1016/j.cell.2005.02.008 – volume: 98 start-page: 1711 year: 2007 ident: 515_CR4 publication-title: Bioresource Technology doi: 10.1016/j.biortech.2006.07.034 – volume: 43 start-page: 658 year: 2007 ident: 515_CR8 publication-title: Free Radical Biology and Medicine doi: 10.1016/j.freeradbiomed.2007.05.037 |
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| SubjectTerms | 2,2-diphenyl-1-picrylhydrazyl acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer disease Animals antioxidant activity Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Butyrylcholinesterase - metabolism cholinesterase Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology chromatography Electrophorus ethyl acetate Free Radical Scavengers - chemistry Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Horses inhibitory concentration 50 macroalgae Medicine nuclear magnetic resonance spectroscopy Phaeophyceae Phaeophycophyta Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology reactive oxygen species Research Article Seaweed silica gel spectral analysis 약학 |
| Title | Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis |
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