Potential Anti-Aging Substances Derived from Seaweeds

Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process are not fully elucidated. However, a growing body of evidence suggests that several pathways, such as sirtuin, AMP-activated protein kinase,...

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Published inMarine drugs Vol. 18; no. 11; p. 564
Main Authors Cao, Lei, Lee, Sang Gil, Lim, Kwon Taek, Kim, Hyeung-Rak
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.11.2020
MDPI
Subjects
Ageing
Aging
Aging - drug effects
Aging - metabolism
Algae
AMP
AMP-activated protein kinase
Animal models
Animals
anti-aging
Antioxidants
Autophagy
bioactive
Bioactive compounds
Biological activity
Biological Products - isolation & purification
Biological Products - pharmacology
Cancer
Cardiovascular diseases
Cell cycle
Cell division
cells
Cellular Senescence - drug effects
chronic diseases
Diabetes
Diabetes mellitus
drugs
exhibitions
extracts
Fatty acids
Fibers
Fibroblasts
Food processing
Food sources
Growth factors
Human subjects
Humans
Immune system
Inflammation
Insects
Insulin
Insulin-like growth factors
Kinases
Life span
longevity
macroalgae
Mammals
Minerals
Molecular modelling
Nutrients
nutritional intervention
Oxidative stress
Phagocytosis
Polyunsaturated fatty acids
Proteins
Review
Risk analysis
Risk factors
Seaweed - metabolism
Seaweeds
Senescence
Signal Transduction
Skin
somatomedins
Vitamins
senescence
seaweeds
anti-aging
macroalgae
bioactive
Online AccessGet full text

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Abstract Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process are not fully elucidated. However, a growing body of evidence suggests that several pathways, such as sirtuin, AMP-activated protein kinase, insulin-like growth factor, autophagy, and nuclear factor erythroid 2-related factor 2 play critical roles in regulating aging. Furthermore, genetic or dietary interventions of these pathways can extend lifespan by delaying the aging process. Seaweeds are a food source rich in many nutrients, including fibers, polyunsaturated fatty acids, vitamins, minerals, and other bioactive compounds. The health benefits of seaweeds include, but are not limited to, antioxidant, anti-inflammatory, and anti-obese activities. Interestingly, a body of studies shows that some seaweed-derived extracts or isolated compounds, can modulate these aging-regulating pathways or even extend lifespans of various animal models. However, few such studies have been conducted on higher animals or even humans. In this review, we focused on potential anti-aging bioactive substances in seaweeds that have been studied in cells and animals mainly based on their anti-aging cellular and molecular mechanisms.
AbstractList Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process are not fully elucidated. However, a growing body of evidence suggests that several pathways, such as sirtuin, AMP-activated protein kinase, insulin-like growth factor, autophagy, and nuclear factor erythroid 2-related factor 2 play critical roles in regulating aging. Furthermore, genetic or dietary interventions of these pathways can extend lifespan by delaying the aging process. Seaweeds are a food source rich in many nutrients, including fibers, polyunsaturated fatty acids, vitamins, minerals, and other bioactive compounds. The health benefits of seaweeds include, but are not limited to, antioxidant, anti-inflammatory, and anti-obese activities. Interestingly, a body of studies shows that some seaweed-derived extracts or isolated compounds, can modulate these aging-regulating pathways or even extend lifespans of various animal models. However, few such studies have been conducted on higher animals or even humans. In this review, we focused on potential anti-aging bioactive substances in seaweeds that have been studied in cells and animals mainly based on their anti-aging cellular and molecular mechanisms.
Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process are not fully elucidated. However, a growing body of evidence suggests that several pathways, such as sirtuin, AMP-activated protein kinase, insulin-like growth factor, autophagy, and nuclear factor erythroid 2-related factor 2 play critical roles in regulating aging. Furthermore, genetic or dietary interventions of these pathways can extend lifespan by delaying the aging process. Seaweeds are a food source rich in many nutrients, including fibers, polyunsaturated fatty acids, vitamins, minerals, and other bioactive compounds. The health benefits of seaweeds include, but are not limited to, antioxidant, anti-inflammatory, and anti-obese activities. Interestingly, a body of studies shows that some seaweed-derived extracts or isolated compounds, can modulate these aging-regulating pathways or even extend lifespans of various animal models. However, few such studies have been conducted on higher animals or even humans. In this review, we focused on potential anti-aging bioactive substances in seaweeds that have been studied in cells and animals mainly based on their anti-aging cellular and molecular mechanisms.Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process are not fully elucidated. However, a growing body of evidence suggests that several pathways, such as sirtuin, AMP-activated protein kinase, insulin-like growth factor, autophagy, and nuclear factor erythroid 2-related factor 2 play critical roles in regulating aging. Furthermore, genetic or dietary interventions of these pathways can extend lifespan by delaying the aging process. Seaweeds are a food source rich in many nutrients, including fibers, polyunsaturated fatty acids, vitamins, minerals, and other bioactive compounds. The health benefits of seaweeds include, but are not limited to, antioxidant, anti-inflammatory, and anti-obese activities. Interestingly, a body of studies shows that some seaweed-derived extracts or isolated compounds, can modulate these aging-regulating pathways or even extend lifespans of various animal models. However, few such studies have been conducted on higher animals or even humans. In this review, we focused on potential anti-aging bioactive substances in seaweeds that have been studied in cells and animals mainly based on their anti-aging cellular and molecular mechanisms.
Author Kim, Hyeung-Rak
Lee, Sang Gil
Cao, Lei
Lim, Kwon Taek
AuthorAffiliation 2 Department of Food Science and Nutrition, Pukyong National University, Busan 48513, Korea; sglee1125@pknu.ac.kr
1 Institute of Marine Life Sciences, Pukyong National University, Busan 48513, Korea; caolei0630@pknu.ac.kr
3 Department of Display Science and Engineering, Pukyong National University, Busan 48513, Korea; ktlim@pknu.ac.kr
AuthorAffiliation_xml – name: 2 Department of Food Science and Nutrition, Pukyong National University, Busan 48513, Korea; sglee1125@pknu.ac.kr
– name: 1 Institute of Marine Life Sciences, Pukyong National University, Busan 48513, Korea; caolei0630@pknu.ac.kr
– name: 3 Department of Display Science and Engineering, Pukyong National University, Busan 48513, Korea; ktlim@pknu.ac.kr
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– sequence: 2
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  fullname: Lee, Sang Gil
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  orcidid: 0000-0002-7023-6057
  surname: Lim
  fullname: Lim, Kwon Taek
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  surname: Kim
  fullname: Kim, Hyeung-Rak
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33218066$$D View this record in MEDLINE/PubMed
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Keywords senescence
seaweeds
anti-aging
macroalgae
bioactive
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PublicationCentury 2000
PublicationDate 20201118
PublicationDateYYYYMMDD 2020-11-18
PublicationDate_xml – month: 11
  year: 2020
  text: 20201118
  day: 18
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Marine drugs
PublicationTitleAlternate Mar Drugs
PublicationYear 2020
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
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Snippet Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular disease, and diabetes. The exact mechanisms underlying the aging process...
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StartPage 564
SubjectTerms Ageing
Aging
Aging - drug effects
Aging - metabolism
Algae
AMP
AMP-activated protein kinase
Animal models
Animals
anti-aging
Antioxidants
Autophagy
bioactive
Bioactive compounds
Biological activity
Biological Products - isolation & purification
Biological Products - pharmacology
Cancer
Cardiovascular diseases
Cell cycle
Cell division
cells
Cellular Senescence - drug effects
chronic diseases
Diabetes
Diabetes mellitus
drugs
exhibitions
extracts
Fatty acids
Fibers
Fibroblasts
Food processing
Food sources
Growth factors
Human subjects
Humans
Immune system
Inflammation
Insects
Insulin
Insulin-like growth factors
Kinases
Life span
longevity
macroalgae
Mammals
Minerals
Molecular modelling
Nutrients
nutritional intervention
Oxidative stress
Phagocytosis
Polyunsaturated fatty acids
Proteins
Review
Risk analysis
Risk factors
Seaweed - metabolism
Seaweeds
Senescence
Signal Transduction
Skin
somatomedins
Vitamins
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Title Potential Anti-Aging Substances Derived from Seaweeds
URI https://www.ncbi.nlm.nih.gov/pubmed/33218066
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Volume 18
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